Glutathione depression by dihydropyrazine derivative
スポンサーリンク
概要
- 論文の詳細を見る
Dihydropyrazine (DHP), which is formed by nonenzymatic glycation, generates various radical species that lead to DNA damage and enzyme inhibition. In this study, we examined the reaction between DHP derivatives and glutathione (GSH). DHP exposure caused more intense growth inhibition of a GSH-deficient mutant Escherichia coli strain compared with the wild-type strain. DHP-exposed mouse fibroblasts showed a decrease in the cellular GSH level. The obtained data suggested that the reaction of DHP with GSH possibly potentiates cellular stress via the depletion of cellular GSH levels.
- 2011-04-01
著者
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Ishii Yuji
九州大学 薬学研究院
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Ishii Y
Graduate School Of Pharmaceutical Sciences Kyushu University
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ITO Shigeru
Institute of Biomaterials and Bioengineering, Tokyo Medical and Dental University
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YAMAGUCHI Tadatoshi
Faculty of Pharmaceutical Sciences, Sojo University
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KASHIGE Nobuhiro
Faculty of Pharmaceutical Sciences, Fukuoka University
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Ishii Yukimoto
Department Of Surgery Nihon University School Of Medicine
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Yamaguchi Tokio
Faculty Of Pharmaceutical Sciences Sojo University
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Ito S
Institute For Medical And Dental Engineering Tokyo Medical And Dental University
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Takeda Shuso
Graduate School Of Pharmaceutical Sciences Kyushu University
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Ishida Takumi
Graduate School Of Pharmaceutical Sciences Kyushu University
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ISHIDA Takumi
Faculty of Pharmaceutical Sciences, Kyushu University
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Takechi Shinji
Faculty Of Pharmaceutical Sciences Sojo University
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Tadatoshi Yamaguchi
Faculty Of Hygiene Miyazaki Medical College
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Yamaguchi Tadatoshi
Faculty Of Pharmaceutical Sciences Sojo University
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Ito Shigeru
Institute For Medical And Dental Engineering Tokyo Medical And Dental University
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Kashige Nobuhiro
Faculty Of Pharmaceutical Sciences Fukuoka University
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Ishida Takumi
Faculty Of Pharmaceutical Sciences Sojo University
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Takechi Shinji
Faculty of Pharmaceutical Science, Sojo University
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Yamaguchi Tadatoshi
Faculty of Pharmaceutical Science, Sojo University
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Kashige Nobuhiro
Faculty of Pharmaceutical Science, Fukuoka University
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