DSC and NMR Spectroscopic Studies of the Interaction between Camphorated Phenol and Phospholipid Liposomes
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概要
- 論文の詳細を見る
To clarify the interaction mechanism of biological activities induced by camphorated phenol (CP), the interactions between CP and phospholipid liposomes [dipalmitoyl phosphatidylcholine (DPPC) liposomes, dimyristoyl phosphatidylcholine (DMPC) liposomes and DMPC/dilauloyl phosphatidylethanolamine (DLEA) liposomes] were studies by DSC and NMR spectroscopy. CP exhibited a larger DSC phase transition properties [shift of phase transition temperature to a lower temperature and decrease in Height/Half-Height Width (H/HHW) of DSC peak)] than phenol in the various liposome systems. It was concluded from the NMR studies that CP is highly incorporated into the DPPC bilayer, the ^1H and ^<13>C signals of phenol in a complex between phenol and camphor being markedly broadened but shielded in the presence of DPPC liposomes. It was clear that CP is incorporated as a complex into the lipid bilayers.
- 日本歯科理工学会の論文
著者
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Fujisawa Seiichiro
Department of Oral Diagnosis, Meikai University School of Dentistry
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ITO Shigeru
Institute of Biomaterials and Bioengineering, Tokyo Medical and Dental University
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Kadoma Yoshinori
Institute Of Biomaterials And Bioengineering Tokyo Medical And Dental University
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Kadoma Yoshinori
Institute For Medical And Dental Engineering Tokyo Medical And Dental University
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Fujisawa Seiichiro
Department Of Oral Diagnosis School Of Dentistry. Meikai University
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Ito S
Institute For Medical And Dental Engineering Tokyo Medical And Dental University
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Ito Shigeru
Institute For Medical And Dental Engineering Tokyo Medical And Dental University
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