Phenyl-Substituted Dihydropyrazines with DNA Strand-Breakage Activity
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概要
- 論文の詳細を見る
Monophenyl-substituted dihydropyrazines (Ph-DHP-1 to 4) of 2,3-dihydro-5,6-dimethylpyrazine (Me-DHP-1), which have the inductive effects of apoptosis and mutagenesis, were synthesized and their biological effect was investigated in terms of DNA strand-breakage. Differences between the phenyl- and methyl-substituted dihydropyrazines were examined.
著者
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TAKECHI Shinji
Faculty of Pharmaceutical Sciences, Sojo University
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ITO Shigeru
Institute of Biomaterials and Bioengineering, Tokyo Medical and Dental University
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YAMAGUCHI Tadatoshi
Faculty of Pharmaceutical Sciences, Sojo University
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KASHIGE Nobuhiro
Faculty of Pharmaceutical Sciences, Fukuoka University
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Ito S
Institute For Medical And Dental Engineering Tokyo Medical And Dental University
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Takeda Shuso
Graduate School Of Pharmaceutical Sciences Kyushu University
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Takechi Shinji
Dept. Biochem. Miyazaki Med. Coll.
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Nakahara Kazuhide
Faculty of Pharmaceutical Sciences, Sojo University
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Takechi Shinji
Faculty Of Pharmaceutical Sciences Sojo University
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Yamaguchi Tadatoshi
Faculty Of Pharmaceutical Sciences Sojo University
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Ito Shigeru
Institute For Medical And Dental Engineering Tokyo Medical And Dental University
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Kashige Nobuhiro
Faculty Of Pharmaceutical Sciences Fukuoka University
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Takechi Shinji
Faculty of Pharmaceutical Science, Sojo University
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Yamaguchi Tadatoshi
Faculty of Pharmaceutical Science, Sojo University
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Kashige Nobuhiro
Faculty of Pharmaceutical Science, Fukuoka University
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