Glutathione depression by dihydropyrazine derivative
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概要
- 論文の詳細を見る
Dihydropyrazine (DHP), which is formed by nonenzymatic glycation, generates various radical species that lead to DNA damage and enzyme inhibition. In this study, we examined the reaction between DHP derivatives and glutathione (GSH). DHP exposure caused more intense growth inhibition of a GSH-deficient mutant Escherichia coli strain compared with the wild-type strain. DHP-exposed mouse fibroblasts showed a decrease in the cellular GSH level. The obtained data suggested that the reaction of DHP with GSH possibly potentiates cellular stress via the depletion of cellular GSH levels.
- 日本トキシコロジー学会の論文
著者
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TAKECHI Shinji
Faculty of Pharmaceutical Sciences, Sojo University
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ITO Shigeru
Institute of Biomaterials and Bioengineering, Tokyo Medical and Dental University
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YAMAGUCHI Tadatoshi
Faculty of Pharmaceutical Sciences, Sojo University
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KASHIGE Nobuhiro
Faculty of Pharmaceutical Sciences, Fukuoka University
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Ito S
Institute For Medical And Dental Engineering Tokyo Medical And Dental University
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ISHIDA Takumi
Faculty of Pharmaceutical Sciences, Kyushu University
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