Chemical Reactivity of Dihydropyrazine Derivatives. Cycloaddition Behavior toward Ketenes
スポンサーリンク
概要
- 論文の詳細を見る
The cycloaddition behavior of dihydropyrazines toward ketenes was investigated using single-crystal X-ray structures of the cycloadducts and density functional theory (DFT) calculation data. The reaction proceeds via a stepwise pathway involving an orientation complex prior to formation of the betaine intermediate. This is followed by electrocyclization to afford the 1 : 1 and 1 : 2 adducts bearing β-lactam ring(s).
- 公益社団法人 日本薬学会の論文
著者
-
HARANO Kazunobu
Faculty of Pharmaceutical Sciences, Sojo University
-
YAMAGUCHI Tadatoshi
Faculty of Pharmaceutical Sciences, Sojo University
-
Yamaguchi Koki
Faculty of Pharmaceutical Sciences, Sojo University
-
Yoshitake Yasuyuki
Faculty of Pharmaceutical Sciences, Sojo University
-
Nakahara Kazuhide
Faculty of Pharmaceutical Sciences, Sojo University
-
Harano Kazunobu
Faculty Of Pharmaceutical Sciences Kumamoto University
-
Yamaguchi Tadatoshi
Faculty Of Pharmaceutical Sciences Sojo University
-
Yoshitake Yasuyuki
Faculty of Phamaceutical Sciences, Sojo University
-
Yamaguchi Koki
Faculty of Phamaceutical Sciences, Sojo University
-
Yamaguchi Tadatoshi
Faculty of Pharmaceutical Science, Sojo University
-
Harano Kazunobu
Faculty of Phamaceutical Sciences, Sojo University
関連論文
- Molecular Orbital Analysis of Antioxidative Activity of Phenolics from Tessaria integrifolia and Piper elongatum
- Effects of Phenyl Derivatives of Dihydropyrazines with Ability to Generate Radical Species on Escherichia coli(Biochemistry)
- P-229 NEW STEROIDAL GLYCOSIDES FROM TUBOCAPSICUM ANOMALUM
- Latent Enamine Functionality of 5-Methyl-2,3-dihydropyrazines
- Nuclectide Sequence Specificity in DNA Cleavage Caused by Dihydropyrazines, a New Type of DNA Strand-Cleaving Agent
- A Carbon-Centered Radical as a Reaction Species in the DNA Strand-Breakage by D-Glucosamine
- Dihydropyrazine Derivatives as a New Type of DNA Strand Breaking Agent
- FORMATION OF TRICYCLIC HETEROCYCLES FROM THE CONDENSATION REACTION OF 1,2-DIAMINES WITH 1,2-DIKETONES
- New C_ Steroidal Glycosides from Tubocapsicum anomalum
- A New Homostilbene and Two New Homoisoflavones from the Bulbs of Scilla scilloides
- New C_ Steroidal Glycosides from Tubocapsicum anomalum
- Synthesis and DNA Strand Breakage Activity of Some 1,4-Diazepines
- Reaction of 2,3-Butanedione with Propylenediamine Observed by 1H-NMR Spectroscopy
- Oxidative Stress Induced by a Dihydropyrazine Derivative(Molecular and Cell Biology)
- 2,3,7,8-Tetrachlorodibenzo-p-dioxin potentially attenuates the gene expression of pituitary gonadotropin β-subunits in a fetal age-specific fashion: a comparative study using cultured pituitaries
- Dihydropyrazine-Induced Inactivation of Glyceraldehyde-3-phosphate Dehydrogenase
- Atropisomers of 1-(Acyl or Aroyl)-2-naphthylinolines. Isolation, X-Ray Crystal Structure and Confermational Analysis
- Mutation Spectrum Induced by Dihydropyrazines in Escherichia coli(Molecular and Cell Biology)
- The Role of Dihydropyrazines in Accelerated Death of Escherichia coli on Addition of Copper (II)(Molecular and Cell Biology)
- Radical Species in DNA Strand-Cleavage Caused by Dihydropyrazines(Biochemistry/Molecular Biology)
- Synthesis of New Dihydropyrazines with DNA Strand-Breakage Activity
- CHLOROPHYLL-PORPHYRIN CATABOLISM : PRODUCTION OF A BILIRUBIN-LIKE PIGMENT IN VITRO
- CHLOROPHYLL CATABOLISM AND ITS PHYSIOLOGICAL SIGNIFICANCE IN HIGHER PLANTS
- THE PRIMARY STEP IN CHLOROPHYLL CATABOLISM IN HIGHER PLANTS
- A Diamine-Exchange Reaction of Dihydropyrazines
- Products from a Novel Reaction of Dihydropyrazines whith Vichinaldiamines
- Pericyclic Reaction Behavior of Cyclopentadienones toward Acyclic Conjugated Dienes. [3,3]-Sigmatropic Rearrangement and Double Diels-Alder Reactions of the endo[4+2]π Cycloadducts
- Formation Mechanism of Furfuryl Sulfides from O-Furfuryl Dithiocarbonates: Density Functional Theory Study for Aromatic [3,3]-Sigmatropic Rearrangement
- New Formation Mechanism of Allylic Trithiocarbonates from Sodium O-(2-Alkenyl) Dithiocarbonates via Sequential Pericyclic Reactions: Density Functional Theory Study
- Crystallographic Evidence for Cyclopropane Ring Formation in Isotwistenes Obtained by Thermal Cascade Reactions of Cyclopentadienone with Acyclic Conjugated Dienes
- Cascade Reaction of Imines with Phenylsulfinylallene. X-Ray Structure of the Product and Its Formation Mechanism
- Molecular Orbital Studies on Pericyclic Reactions of Cinnamyl Xanthates in β-Cyclodextrin Cavities
- Crystallographic and Molecular Orbital Studies of 4-Oxopyrazole 1,2-Dioxides. An Exceptionally Elongted N-N Bond
- Chemical Reactivity of Dihydropyrazine Derivatives. Cycloaddition Behavior toward Ketenes
- Tetraazaindenes Derived from Dihydropyrazines with DNA Strand-Breaking Activity
- Phenyl-Substituted Dihydropyrazines with DNA Strand-Breakage Activity
- Glutathione depression by dihydropyrazine derivative
- The Relationship between the Chemical Structures of Dihydropyrazine Derivatives and DNA Strand-Breakage Activity
- 2,3,7,8-Tetrachlorodibenzo-p-dioxin potentially attenuates the gene expression of pituitary gonadotropin β-subunits in a fetal age-specific fashion : a comparative study using cultured pituitaries
- A Theoretical Study of Neighboring-Group Participation in Thione-to-Thiol Rearrangement of Xanthates. Molecular Orbital Calculation Using a Conductor-Like Screening Model (COSMO) Approach
- Glutathione depression by dihydropyrazine derivative
- Possible involvement of glutathione balance disruption in dihydropyrazine-induced cytotoxicity on human hepatoma HepG2 cells
- Generation of Radical Species from Dihydropyrazines Having DNA Strand-Breakage Activity and Other Characteristics