Tetraazaindenes Derived from Dihydropyrazines with DNA Strand-Breaking Activity

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概要

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• Dihydropyrazines (DHPs), which exhibit DNA strand-breaking activity and other biological activities associated with the generation of radical species, reacted with thiourea to give tetraazaindene (TAI) derivatives, despite thiourea is a well known radical scavenger. The structural determination of the TAIs was carried out and formation mechanism of TAI was investigated.

• 公益社団法人　日本薬学会の論文

著者

• HARANO Kazunobu

  Faculty of Pharmaceutical Sciences, Sojo University

• TAKECHI Shinji

  Faculty of Pharmaceutical Sciences, Sojo University

• YAMAGUCHI Tadatoshi

  Faculty of Pharmaceutical Sciences, Sojo University

• Yamaguchi Koki

  Faculty of Pharmaceutical Sciences, Sojo University

• Takeda Shuso

  Graduate School Of Pharmaceutical Sciences Kyushu University

• Takechi Shinji

  Dept. Biochem. Miyazaki Med. Coll.

• Nakahara Kazuhide

  Faculty of Pharmaceutical Sciences, Sojo University

• Harano Kazunobu

  Faculty Of Pharmaceutical Sciences Kumamoto University

• Takechi Shinji

  Faculty Of Pharmaceutical Sciences Sojo University

• Yamaguchi Tadatoshi

  Faculty Of Pharmaceutical Sciences Sojo University

• Yamaguchi Koki

  Faculty of Phamaceutical Sciences, Sojo University

• Takechi Shinji

  Faculty of Pharmaceutical Science, Sojo University

• Yamaguchi Tadatoshi

  Faculty of Pharmaceutical Science, Sojo University

• Harano Kazunobu

  Faculty of Phamaceutical Sciences, Sojo University

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