Modulation of UDP-Glucuronosyltransferase 2B7 Function by Cytochrome P450s in Vitro : Differential Effects of CYP1A2, CYP2C9 and CYP3A4(Communications to the Editor)
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概要
- 論文の詳細を見る
Effects of cytochrome P450 isoforms, CYP1A2, CYP2C9 and CYP3A4, on the catalytic activity of UDP-glucuronosyltransferase 2B7 (UGT2B7) expressed in COS cell microsomal membranes were investigated using morphine as a substrate. When detergent-untreated COS cell microsomes were used as the enzyme source, the activity of morphine-3-glucuronide formation by UGT2B7 was reduced by addition of purified CYP1A2 and CYP2C9 in a concentration-dependent manner. The effect of CYP1A2 was greater than that of CYP2C9. In contrast, exogenous CYP3A4 had little effect on morphine glucuronidation activity. These results suggest that CYP1A2 and CYP2C9 have ability to modify UGT2B7 function. However, the mechanism(s) underlying the modulation of UGT2B7 function by these P450s seems to differ from that by CYP3A4.
- 社団法人日本薬学会の論文
- 2005-10-01
著者
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Ishii Yuji
Graduate School of Pharmaceutical Sciences, Kyushu University
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Yamada Hideyuki
Graduate School of Pharmaceutical Sciences, Kyushu University
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Nagata Kiyoshi
東北大学 薬学研究科薬物動態学
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Nagata Kiyoshi
Division Of Drug Metabolism And Molecular Toxicology Graduate School Of Pharmaceutical Sciences Toho
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Ishii Yuji
Graduate School Of Pharmaceutical Sciences Kyushu Univ.
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Ishii Yuji
九州大学 薬学研究院
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Yamazoe Yasushi
東北大学 薬学研究科薬物動態学
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Nagata Kiyoshi
九州大学 薬学研究院
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Ishii Y
Graduate School Of Pharmaceutical Sciences Kyushu University
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Yamazoe Yasushi
Graduate School Of Pharmaceutical Sciences Tohoku University
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TAKEDA Shuso
Graduate School of Pharmaceutical Sciences, Kyushu University
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MACKENZIE Peter
Department of Clinical Pharmacology, Flinders Medical Centre and Flinders University
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NAGATA Kiyoshi
Graduate School of Pharmaceutical Sciences, Tohoku University
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OGURI Kazuta
School of Pharmaceutical Sciences, Kyushu University of Health and Welfare
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Oguri K
School Of Pharmaceutical Sciences Kyushu University Of Health And Welfare
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Mackenzie Peter
Department Of Clinical Pharmacology Flinders Medical Centre And Flinders University
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Yamazoe Y
Tohoku Univ. Sendai Jpn
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Ishii Yukimoto
Department Of Surgery Nihon University School Of Medicine
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Oguri Kazuta
School Of Pharmaceutical Sciences Kyushu University Of Health And Welfare
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Oguri K
Faculty Of Pharmaceutical Sciences Kyushu University
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Oguri K
Kyushu Univ. Fukuoka Jpn
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Ishii Yuri
Central Research Laboratory Fancl Corporation
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Takeda Shuso
Graduate School Of Pharmaceutical Sciences Kyushu University
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Yamada Hideyuki
Graduate School Of Pharmaceutical Sciences Kyushu University
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Yamada H
Faculty Of Pharmaceutical Sciences Kyushu University
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Yamada H
Graduate School Of Pharmaceutical Sciences Kyushu University
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Yamada Hideyuki
Graduate School Of Engineering Osaka Prefecture University
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Nagata K
Department Of Environmental And Health Science Tohoku Pharmaceutical University
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Yoshimura Hidetoshi
Department Of Food And Nutrition Nakamura Gakuen
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Oguri Kazuta
Faculty Of Pharmaceutical Sciences Kyushu University:(present Address)laboratory Of Safety Assessment Panapharm Laboratories Co. Ltd.:(present Address)department Of Food And Nutrition Nakamura Gakuen College
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