Safety of Garcinia cambogia Extract in Healthy Volunteers : High-Dose Administration Study II
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概要
- 論文の詳細を見る
The purpose of this study was to review the safety of long-term excessive ingestion of Garcinia extract. For 12 weeks, a dosage of 5000 mg Garcinia extract powder (3000 mg/day as (-)-hydroxycitric acid [(-)-HCA]) was administered to healthy subjects (men 24, women 24). Hematology, hemobiochemistry, endocrinology and urinalysis were carried out every four weeks. Endocrinologically, serum inhibin B increased in men (P<0.05), from 162.1 ± 46.2 pg/mL to 186.7 ± 61.6 pg/mL. In addition, Follicle Stimulating Hormone (FSH) increased (P<0.05), from 4.68 ± 2.65 mIU/mL to 5.18 ± 2.75 mIU/mL. It is hard to conceive the changes had a testiculus influence, because the changes were very slight and no reciprocal relationships existed between them. In women, no significant change of sex hormone was noted and no influence on menstrual cycles was observed. Neither remarkable changes in hematology, hemobiochemistry and urinalysis nor adverse events were observed. These findings support the safety for humans of long-term excessive administration of Garcinia extract (3000 mg/day as HCA, 12 weeks) was high.
- 日本油化学会の論文
- 2003-12-01
著者
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Shimasaki Hiroyuki
Department of Health and Nutrition, University of Human Arts and Sciences
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Ishii Yuji
九州大学 薬学研究院
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YOSHINO Gen
Departments of Laboratory Medicine, Ohashi and Omori Hospitals, School of Medicine, Toho University
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Ishii Y
Graduate School Of Pharmaceutical Sciences Kyushu University
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Shimasaki H
Teikyo Univ. School Of Medicine Tokyo Jpn
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Yoshino Gen
Department Of Laboratory Medicine Toho University School
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SHIGEMATSU Norihiro
Central Research Laboratory, FANCL Co., Ltd.
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Ishii Yukimoto
Department Of Surgery Nihon University School Of Medicine
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Yoshino Gen
Department Of Diabetes And Endocrinology Toho University Omori Medical Center
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Shimasaki Hiroyuki
Department Of Biochemistry Teikyo University School Of Medicine
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Shigematsu Norihiro
Central Research Laboratory Fancl Corporation
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Shigematsu Norihiro
Biosci.textile Technol. Shinshu University
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Ishii Y
Laboratory Of Molecular Life Science Graduate School Of Pharmaceutical Sciences Kyushu University
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Ishii Yuri
Central Research Laboratory Fancl Corporation
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HAYAMIZU Kohsuke
Central laboratory, FANCL Corporation
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KANEKO Izuru
Central laboratory, FANCL Corporation
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SHEN Manzhen
Central laboratory, FANCL Corporation
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Kaneko Izuru
Central Research Laboratory Fancl Corporation
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Shen Manzhen
Central Research Laboratory Fancl Corporation
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TOMI Hironori
Food Development Laboratories, Nippon Shinyaku Corporation
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Tomi H
Nippon Shinyaku Co. Ltd. Kyoto Jpn
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Tomi Hironori
Food Development Laboratories Nippon Shinyaku Co. Ltd.
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Shimasaki Hiroyuki
帝京大医第一生化
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Yoshino G
Department Of Laboratory Medicine Toho University School
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Shimasaki H
Dep. Of Health And Nutrition Univ. Of Arts And Sciences
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Hayamizu Kohsuke
Central Research Laboratory Fancl Corporation
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SHIGEMATSU Norihiro
Central laboratory, FANCL Corporation
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ISHII Yuri
Central laboratory, FANCL Corporation
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