Effects of Soybean-germ Oil on Reducing Serum Cholesterol Levels in a Double-Blind Controlled Trial in Healthy Humans
スポンサーリンク
概要
- 論文の詳細を見る
Soybean-germ oil was extracted from hypocotyle enriched raw soybean and was found to contain 4 times as much plant sterol as soybean oil. Its capacity for cholesterol-lowering effects in humans was evaluated using a double-blind, controlled protocol. Forty-nine healthy male volunteers, average age 45 (SD11), with serum total cholesterol (TC) below 260 mg/dl, consumed test food everyday for 12 weeks. The test food was mayonnaise containing 11 g cooking oil. The test groups were i) 11 g Soybean-germ oil and ii) 11 g safflower oil group (Control group). In the sub-group of subjects with initial TC above 220 mg/day, serum TC in Soybean-germ oil group decreased significantly (4wk: p < 0.01, 8wk: p < 0.05) and it was lower than that in the Control group throughout the test period. This effect may be mainly due to the inhibiting cholesterol absorption of plant sterols contained in Soybean-germ oil. These results suggest that daily intake of Soybean-germ oil can be effective for maintaining normal serum cholesterol level in humans.
- 日本油化学会の論文
- 2004-01-01
著者
-
ITAKURA Hiroshige
Department of Food Science, Ibaraki Christian University, College of Life Science
-
Shimasaki Hiroyuki
Department of Health and Nutrition, University of Human Arts and Sciences
-
Itakura H
Department Of Food Science Ibaraki Christian University
-
Itakura Hiroshige
コカコーラ東京研究開発センター
-
Itakura Hiroshige
明治製菓
-
Itakura H
Ibaraki Christian Univ. Ibaraki Jpn
-
Itakura H
National Inst. Health And Nutrition Tokyo Jpn
-
Shimasaki H
Teikyo Univ. School Of Medicine Tokyo Jpn
-
Sakai K
Food Research & Development Laboratories Ajinomoto Co. Inc.
-
Itakura Hiroshige
Department Of Food Sciences Ibaraki Christian University
-
Itakura Hiroshige
Division Of Clinical Nutrition National Institute Of Health And Nutrition
-
SATO Hitoshi
Food Research & Development Laboratories, Ajinomoto Co. , Inc.
-
ITO Kazuko
Food Research & Development Laboratories, Ajinomoto Co. , Inc.
-
SAKAI Keiichi
Food Research & Development Laboratories, Ajinomoto Co. , Inc.
-
MORINAGA Yasushi
Institute of Life Sciences, Ajinomoto Co. , Inc.
-
TASHIMA Ikukazu
Products Development Department, Ajinomoto Oil Mills Co. , Inc.
-
SUKEGWA Eiji
Research Institute for Health Fundamentals, Ajinomoto Co. , Inc.
-
Itakura Hiroshige
Department Of Food Science Ibaraki Christian University
-
Shimasaki Hiroyuki
Department Of Biochemistry Teikyo University School Of Medicine
-
Ito Kazuko
Food Research & Development Laboratories Ajinomoto Co. Inc.
-
Sukegwa Eiji
Research Institute For Health Fundamentals Ajinomoto Co. Inc.
-
Ito Ken-ich
Laboratory Of Japan Pmc Co. Ltd.
-
Shimasaki Hiroyuki
帝京大医第一生化
-
Morinaga Y
Institute Of Life Sciences Ajinomoto Co. Inc.
-
Tashima Ikukazu
Products Development Department Ajinomoto Oil Mills Co. Inc.
-
Shimasaki H
Dep. Of Health And Nutrition Univ. Of Arts And Sciences
-
Sato Hitoshi
Food Research & Development Laboratories Ajinomoto Co. Inc.
関連論文
- Evaluation of Safety of Excessive Intake and Efficacy of Long-term Intake of Beverages Containing Apple Polyphenols
- Incremental Effects of Eicosapentaenoic Acid on Cardiovascular Events in Statin-Treated Patients With Coronary Artery Disease : Secondary Prevention Analysis From JELIS
- PJ-512 The Relationship between Plasma Fatty Acids Composition and Serum Lipoproteins in Hyperchoresterolemic Patients : Findings from JELIS(Lipid disorders-3, The 71st Annual Scientific Meeting of the Japanese Circulation Society)
- 2 Major Outcomes and Safety of EPA Derived from the Japan EPA LIPID INTERVENTION STUDY (JELIS)(Late Breaking Clinical Trials in Japan,The 70th Anniversary Annual Scientific Meeting of the Japanese Circulation Society)
- Effects of α-Linolenic Acid-rich Diacylglycerol Intake on the Oxidation of Dietary Fats in Rats
- Effect of Tea Catechins on the Oxidation of Dietary Lipids in Rats〔和文〕
- Suppressive Effect of Cocoa Powder on Atherosclerosis in Kurosawa and Kusanagi-hypercholesterolemic Rabbits
- Analysis of the Comprehensive Effects of Polyunsaturated Fatty Acid on mRNA Expression Using a Gene Chip
- Influence of Polyunsaturated Fatty Acid on Gene Expression in HepG2 Cells
- Antioxidant Ability of Various Flavonoids against DPPH Radicals and LDL Oxidation
- Lipoprotein Analysis Using Agarose Gel Electrophoresis and Differential Staining of Lipids
- Inhibition of Low-Density Lipoprotein Oxidation by Astaxanthin
- Regulation of Hepatic High Density Lipoprotein Binding Protein, HB_2, Expression after Administration of Simvastatin to Rabbits
- Effects of Cacao Liquor Polyphenols on the Susceptibility of Low-density Lipoprotein to Oxidation in Hypercholesterolemic Rabbits
- Antioxidant Effects of Polyphenols in Chocolate on Low-Density Lipoprotein both In Vitro and Ex Vivo
- Antioxidative Effects of Choi-joki-to and its Ability to Inhibit the Progression of Atheroma in KHC Rabbits
- A Candidate High Density Lipoprotein (HDL) Receptor, HB_2, with Possible Multiple Functions Shows Sequence Homology with Adhesion Molecules
- Analysis of (-)-Epigallocatechin Gallate in Human Serum Obtained after Ingesting Green Tea
- Suppressive Mechanisms of EPA on Human T Cell Proliferation
- THE RELATIONSHIP BETWEEN DNA POLYMORPHISMS OF APOPROTEIN A-I,B OR E GENE AND SEVERITY OF ANGIOGRAPHICALLY DEFINED CORONARY ARTERY DISEASE
- Long-term safety, tolerability, and antihypertensive efficacy of aliskiren, an oral direct renin inhibitor, in Japanese patients with hypertension
- Aliskiren, a Novel Oral Renin Inhibitor, Provides Dose-Dependent Efficacy and Placebo-Like Tolerability in Japanese Patients with Hypertension
- Effects of Soybean-germ Oil on Reducing Serum Cholesterol Levels in a Double-Blind Controlled Trial in Healthy Humans
- Effects of Soybean-germ Oil on Reducing Serum Cholesterol Level〔和文〕
- Gene expression related to cholesterol metabolism in mouse brain during development
- Effects of Dietary α-Linolenic Acid-rich Diacylglycerol on Body Fat in Man(1)Lowering Effect on Body Fat〔和文〕
- Dietary Tea Catechins Reduce Development of Obesity Accompanied with Gene Expression of Lipid-metabolizing Enzymes in Mice〔和文〕
- Tea Catechins Suppress Accumulation of Body Fat in Humans〔和文〕
- Effects of α-Linolenic Acid-rich Diacylglycerol on Diet-induced Obesity in Mice
- Anti-obesity Effects of Tea Catechins in Humans〔和文〕
- Effects of Tea Catechins on Diet-induced Obesity in Mice〔和文〕
- Allele Frequency of Apolipoprotein Gene Polymorphisms and Association between Genotype and Serum Lipid and Apolipoprotein Levels
- Effects of Dietary α-Linolenic Acid-rich Diacylglycerol on Body Fat in Man(2)Effects on Resting Metabolism and Fat Metabolism〔和文〕
- Effect of Tea Catechins on Energy Metabolism in Rats〔和文〕
- Effect of Yogurt Supplemented with Brewer's Yeast Cell Wall on Levels of Blood Lipids in Normal and Hypercholesterolemic Adults
- Effects of Brewer's Yeast Cell Wall on Fecal Steroid Excretion in Rats
- Generation of 7-ketocholesterol by a Route Different from the Decomposition of Cholesterol 7-hydroperoxide
- Fractionation of the Neutral Lipids of Rice-bran Oil by Centrifugal Liquid Chromatography
- Acetobacter xylinum Mutant with High Cellulose Productivity and an Ordered Structure
- Relationship between the Physical Properties and Surface Area of Cellulose Derived from Adsorbates of Various Molecular Sizes.
- Acetylation of Bacterial Cellulose : Preparation of Cellulose Acetate Having a High Degree of Polymerization
- Degree of Polymerization of Cellulose from Acetobacter xylinum BPR2001 Decreased by Cellulase Produced by the Strain
- Emulsion-stabilizing Effect of Bacterial Cellulose
- Evidence for the Periodically Alternating Microfibrillar Structure of Bacterial Cellulose
- Effects of Long-term Administration of Garcinia cambogia extract on Visceral Fat Accumulation in Humans: A Placebo-controlled Double Blind Trial〔和文〕
- Comparison of the fatty acid composition of total lipids and phospholipids in breast milk from Japanese women
- The Comparison of Fatty Acid Compositions betwteen Total Lipids and Phospholipids in Breast Milk from Japanese Women
- Safety of Garcinia cambogia Extract in Healthy Volunteers : High-Dose Administration Study II
- Safety of Garcinia cambogia Extract in Healthy Men: High-Doses Administration Study I
- 2. Antioxidant Action of the Vitamin E Derivative 1-(11-Selenadodecyl)-3-(6-hydroxy-2, 5, 7, 8-tetramethylchromane-2-acyl)-glycerol against Lipid Peroxidation
- No-Observed-Adverse-Effect level (NOAEL) and Sequential-High-Doses Administration Study on Garcinia cambogia Extract in Humans
- (第303回脂溶性ビタミン総合研究委員会研究発表要旨)
- Threonine Production by Co-existence of Cloned Genes Coding Homoserine Dehydrogenase and Homoserine Kinase in Brevibacterium lactofermentum(Microbiology & Fermentation Industry)
- Determination of the Complete Nucleotide Sequence of Brevibacterium lactofermentum Plasmid pAM330 and Analysis of Its Genetic Information(Biological Chemistry)
- Versatile Cloning Vectors Constructed with Genes Indigenous to a Glutamic Acid-Producer, Brevibacterium lactofermentum(Microbiology & Fermentation Industry)
- Retention behavior of size and aluminum components on handsheets in rosin-ester size/alum systems
- Dietary Fish Oil for Hens Affects the Fatty Acid Composition of Egg Yolk Phospholipids and Gives a Valuable Food with an Ideal Balance of n-6 and n-3 Essential Fatty Acids for Human Nutrition
- Long-term event monitoring study of fluvastatin in Japanese patients with hypercholesterolemia : Efficacy and incidence of cardiac and other events in elderly patients ($ge;65 years old)
- Double-Blind, Placebo-Controlled Study of Effects of Plant Sterol Enriched Vegetable Juice on Serum Cholesterol Concentrations in Mildly Hypercholesterolemic Subjects and Safety Evaluation
- Dietary Effect of Docosahexaenoic Acid-rich Eggs on Serum Lipids in Healthy Human Subjects: A Randomized Double-Blind Controlled Study〔和文〕
- Apple Polyphenols Influence Cholesterol Metabolism in Healthy Subjects with Relatively High Body Mass Index
- Serum Cholesterol-Lowering Effect of Apple Polyphenols in Healthy Subjects
- Chemical Composition of Soybean Oil Extracted from Hypocotyle-Enriched Soybean Raw Material and Its Cholesterol Lowering Effects in Rats
- Effects of Antioxidants on the Oxidative Susceptibility of Low-Density Lipoprotein
- Analysis of the Comprehensive Effects of Polyunsaturated Fatty Acid on mRNA Expression Using a Gene Chip
- Preventive Effects of Eicosapentaenoic Acid on Coronary Artery Disease in Patients With Peripheral Artery Disease : Subanalysis of the JELIS Trial