Monitoring Expression of Cytochrome P450 Genes During Postischemic Rat Liver Reperfusion Using DNA Microarrays

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概要

• 論文の詳細を見る

• We investigated the expression of 50 cytochrome P450 (CYP) genes in the postischemic reperfused rat liver using a DNA microarray. Thirteen CYPs showed absent expression in all experiments and 2 CYPs were induced by pentobarbital, which was used as an anesthetic. Eight of the remaining 35CYPs showed significantly decreased expression following ischemia-reperfusion. Monitoring CYP expression may be a powerful approach for elucidation of pathways regulating drug metabolism that may be involved in postischemic reperfusion liver injury.

• 社団法人 日本薬理学会の論文
• 2005-01-20

著者

• Ishii Yuji

  九州大学 薬学研究院

• Ishikawa K

  Surgery Division Arita Gastrointestinal Hospital

• Ishii Y

  Graduate School Of Pharmaceutical Sciences Kyushu University

• NISHIDA Yayoi

  Division of Genomic Epidemiology and Clinical Trials, Nihon University School of Medicine

• TAKAHASHI Yasuo

  Division of Genomic Epidemiology and Clinical Trials, Nihon University School of Medicine

• ISHIKAWA Koichi

  Department of Pharmacology, Nihon University School of Medicine

• ASAI Satoshi

  Division of Genomic Epidemiology and Clinical Trials, Nihon University School of Medicine

• Nishida Yayoi

  Division Of Genomic Epidemiology And Clinical Trials Nihon University School Of Medicine

• ISHII Yukimoto

  Department of Digestive Surgery

• Ishii Yukimoto

  Department Of Surgery Nihon University School Of Medicine

• Takahashi Yasuo

  Fourth Department Of Internal Medicine Sapporo Medical University School Of Medicine

• Ishikawa Koichi

  Department Of Pharmacology Nihon University School Of Medicine

• Ishii Y

  Laboratory Of Molecular Life Science Graduate School Of Pharmaceutical Sciences Kyushu University

• Ishii Yuri

  Central Research Laboratory Fancl Corporation

• Asai Satoshi

  Division Of Genomic Epidemiology And Clinical Trials Nihon University School Of Medicine

• Ishikawa K

  Department Of Pharmacology Nihon University School Of Medicine

• Takahashi Yasuo

  Department Of Internal Medicine Higashi Sapporo Hospital

• Ishikawa Koichi

  Department Of Industrial Chemistry Faculty Of Technology Tokyo Metropolitan University

• Takahashi Yasuo

  Division Of Genomic Epidemiology And Clinical Trials Nihon University School Of Medicine

• Takahashi Yasuo

  Division Of Genomic Epidemiology And Clinical Trials Advanced Medical Research Center

• Asai Satoshi

  Division Of Genomic Epidemiology And Clinical Trials Advanced Medical Research Center

• Takahashi Yasuo

  Division Of Genetic And Genomic Medicine Advanced Medical Research Center Nihon University School Of

• Asai Satoshi

  Division Of Genetic And Genomic Medicine Advanced Medical Research Center Nihon University School Of Medicine

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