Safety of Garcinia cambogia Extract in Healthy Men: High-Doses Administration Study I

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概要

• 論文の詳細を見る

• (-)-Hydroxycitric acid (HCA), a competitive inhibitor of ATP-citrate lyase, is frequently used in dietary supplements for weight loss. Recently, it was reported in a 52w toxicity study that Garcinia extract powder induced testicular atrophy in rats. In order to study the safety, Garcinia extract was administered to 10 healthy adult men at dose of 3,000 mg/day as HCA for 30 days. No toxicological changes were observed on anthropometric indices or clinical analysis. In addition, serum testosterone showed no change throughout the test period. In regard to subjective symptoms, very slight anorexia (two cases) and headache (one case) occurred. Therefore, we consider that Garcinia extract is safe as administered under the condition of this study.

• 日本油化学会の論文
• 2003-09-01

著者

• Shimasaki Hiroyuki

  Department of Health and Nutrition, University of Human Arts and Sciences

• OKUHARA Yasuhide

  FANCL Research Institute, FANCL Corporation

• YOSHINO Gen

  Departments of Laboratory Medicine, Ohashi and Omori Hospitals, School of Medicine, Toho University

• Shimasaki H

  Teikyo Univ. School Of Medicine Tokyo Jpn

• FURUSE Mitsuhiro

  Laboratory of Advanced Animal and Marine Bioresources, Graduate School of Bioresource and Bioenviron

• Yoshino Gen

  Department Of Laboratory Medicine Toho University School

• Ishii Yukimoto

  Department Of Surgery Nihon University School Of Medicine

• Yoshino Gen

  Department Of Diabetes And Endocrinology Toho University Omori Medical Center

• Shimasaki Hiroyuki

  Department Of Biochemistry Teikyo University School Of Medicine

• Furuse Mitsuhiro

  Laboratory Of Advanced Animal And Marine Bioresources Faculty Of Agriculture Kyushu University

• Shigematsu Norihiro

  Central Research Laboratory Fancl Corporation

• Shigematsu Norihiro

  Biosci.textile Technol. Shinshu University

• Ishii Y

  Laboratory Of Molecular Life Science Graduate School Of Pharmaceutical Sciences Kyushu University

• Ishii Yuri

  Central Research Laboratory Fancl Corporation

• HAYAMIZU Kohsuke

  Central laboratory, FANCL Corporation

• OKUHARA Yasuhide

  Central laboratory, FANCL Corporation

• TOMI Hironori

  Food Development Laboratories, Nippon Shinyaku Corporation

• SHIGEMASU Norihiro

  Central Research Laboratory, FANCL Corporation

• Tomi H

  Nippon Shinyaku Co. Ltd. Kyoto Jpn

• Tomi Hironori

  Food Development Laboratories Nippon Shinyaku Co. Ltd.

• Shimasaki Hiroyuki

  帝京大医第一生化

• Yoshino G

  Department Of Laboratory Medicine Toho University School

• Shimasaki H

  Dep. Of Health And Nutrition Univ. Of Arts And Sciences

• Hayamizu Kohsuke

  Central Research Laboratory Fancl Corporation

• SHIGEMATSU Norihiro

  Central laboratory, FANCL Corporation

• ISHII Yuri

  Central laboratory, FANCL Corporation

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