Metabolism of Drugs of Abuse : Its Contribution to the Toxicity and the Inter-Individual Differences in Drug Sensitivity
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概要
- 論文の詳細を見る
Abuse of drugs remains a serious and world-wide problem. As exemplified by opioids, there are large inter-individual differences in the effects and toxicity of drugs. However, the mechanism underlying such inter-individual differences remains largely unknown. Since, in many cases, drug metabolism affects the effects of drugs, the different metabolic capacity of individuals may explain these inter-individual differences. In this review, we shall focus on drugs of abuse and survey briefly their metabolism and the enzymes involved. In addition, we shall discuss the putative origin of the inter-individual differences in sensitivity to drugs of abuse.
- 公益社団法人日本薬学会の論文
- 2005-02-01
著者
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Ishii Yuji
Graduate School of Pharmaceutical Sciences, Kyushu University
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Yamada Hideyuki
Graduate School of Pharmaceutical Sciences, Kyushu University
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Ishii Yuji
Graduate School Of Pharmaceutical Sciences Kyushu Univ.
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Ishii Yuji
九州大学 薬学研究院
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Ishii Y
Graduate School Of Pharmaceutical Sciences Kyushu University
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OGURI Kazuta
School of Pharmaceutical Sciences, Kyushu University of Health and Welfare
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Oguri K
School Of Pharmaceutical Sciences Kyushu University Of Health And Welfare
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Ishii Yukimoto
Department Of Surgery Nihon University School Of Medicine
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Oguri Kazuta
School Of Pharmaceutical Sciences Kyushu University Of Health And Welfare
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Oguri K
Faculty Of Pharmaceutical Sciences Kyushu University
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Oguri K
Kyushu Univ. Fukuoka Jpn
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Ishii Yuri
Central Research Laboratory Fancl Corporation
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Yamada Hideyuki
Graduate School Of Pharmaceutical Sciences Kyushu University
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Yamada H
Faculty Of Pharmaceutical Sciences Kyushu University
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Yamada H
Graduate School Of Pharmaceutical Sciences Kyushu University
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Yamada Hideyuki
Graduate School Of Engineering Osaka Prefecture University
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Yoshimura Hidetoshi
Department Of Food And Nutrition Nakamura Gakuen
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Oguri Kazuta
Faculty Of Pharmaceutical Sciences Kyushu University:(present Address)laboratory Of Safety Assessment Panapharm Laboratories Co. Ltd.:(present Address)department Of Food And Nutrition Nakamura Gakuen College
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