A New Screening Method for Amphetamine and Methamphetamine Using Dansyl Chloride Derivatization and Cartridge Fluorescence
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概要
- 論文の詳細を見る
A new screening method for ampheramines was developed. It consists of derivatization with dansyl chloride, extraction of the derivative using a Sep-Pak C18 or a Bond Elut C18,solid phase extraction columns, and visualization of the fluorescence of the cartridge. A control test using drug-free urine showed no fluorescence. Amphetamine, methamphetamine and the methylenedioxy derivatives exhibited strong fluorescence, while related compounds, such as N-ethylamphetamine and fenetylline, were negative or weakly positive. The disadvantage of the present method is that it is a multi-step procedure and 20-30 min is required for screening. However, since it has a different specificity from the widely used immunochemical technique, it is suggested to be a useful screen for amphetamines.
- 公益社団法人日本薬学会の論文
- 1998-07-15
著者
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OGURI Kazuta
School of Pharmaceutical Sciences, Kyushu University of Health and Welfare
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Ikeda-wada Sachiko
Kyushu District Narcotic Control Office
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YAMADA Hideyuki
Laboratory of Molecular Life Science, Graduate School of Pharmaceutical Sciences, Kyushu University
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Oguri K
Faculty Of Pharmaceutical Sciences Kyushu University
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Oguri K
Kyushu Univ. Fukuoka Jpn
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Yamada H
Graduate School Of Pharmaceutical Sciences Kyushu University
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OGURI Kazuta
Laboratory of Hygienic and Forensic Chemistry, Faculty of Pharmaceutical Sciences, Kyushu University
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Yoshimura Hidetoshi
Department Of Food And Nutrition Nakamura Gakuen
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