Highly Specific and Convenient Color Reaction for Methylenedioxymethamphetamine and Related Drugs Using Chromotropic Acid. Application as a Drug Screening Test
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概要
- 論文の詳細を見る
The color reaction of various drugs with chromotropic acid and sulfuric acid was examined. Methylenedioxymethamphetamine (MDMA) exhibited a red-violet color on treatment of an aqueous solution with sulfuric acid and chromotropic acid. The specificity of the reaction was examined using 65 drugs. The results showed that while related drugs with a methylenedioxyphenyl moiety, such as methylenedioxy-amphetamine and -N-ethylamphetamine, were all positive, 51 drugs including amphetamine, methamphetamine, opiates, cocaine, and phencyclidine were negative. The drugs exhibiting a positive reaction include tetrahydrocannabinol and related drugs, sulfur-containing drugs such as phenothiazine tranquilizers, and diphenhydramine. These results indicate that the present method is highly specific for MDMA and related drugs although its specificity is not absolute. The detection of MDMA in urine was investigated, and found to be possible using this method.
- 公益社団法人日本薬学会の論文
- 1999-12-31
著者
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Yamada Hideyuki
Graduate School of Pharmaceutical Sciences, Kyushu University
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OGURI Kazuta
School of Pharmaceutical Sciences, Kyushu University of Health and Welfare
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Ikeda-wada Sachiko
Kyushu District Narcotic Control Office
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Oguri Kazuta
Graduate School of Pharmaceutical Sciences, Kyushu University
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Oguri K
Faculty Of Pharmaceutical Sciences Kyushu University
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Oguri K
Kyushu Univ. Fukuoka Jpn
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Oguri Kazuta
Graduate School Of Pharmaceutical Sciences Kyushu University
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Yamada H
Graduate School Of Pharmaceutical Sciences Kyushu University
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Yamada Hideyuki
Graduate School Of Engineering Osaka Prefecture University
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Yoshimura Hidetoshi
Department Of Food And Nutrition Nakamura Gakuen
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