FORMATION OF HIGHLY ANALGESIC MORPHINE-6-GLUCURONIDE FOLLOWING PHYSIOLOGIC CONCENTRATION OF MORPHINE IN HUMAN BRAIN
スポンサーリンク
概要
- 論文の詳細を見る
^3H-Morphine at physiologic concentration was metabolized in vitro to its 3- and 6-glucuronides by human brain homogenate. Recombinant UGT2B7, one of the UDP-glucuronosyltransferase (UGT) isoforms, is able to glucuronidate the 3- and 6-hydroxy groups of morphine at nanomolar concentrations. These results suggest that endogenous morphine is convened to its 6-glucuronide, a more highly analgesic substance than the parent compound, to suppress effectively pain symptoms in humans.
- 日本トキシコロジー学会の論文
- 2003-12-26
著者
-
Ishii Yuji
Graduate School of Pharmaceutical Sciences, Kyushu University
-
Yamada Hideyuki
Graduate School of Pharmaceutical Sciences, Kyushu University
-
Ishii Yuji
Graduate School Of Pharmaceutical Sciences Kyushu Univ.
-
Ishii Yuji
九州大学 薬学研究院
-
Ishii Y
Graduate School Of Pharmaceutical Sciences Kyushu University
-
MORIOKA Takato
Department of Neurosurgery, Graduate School of Medical Sciences, Kyushu University
-
OGURI Kazuta
School of Pharmaceutical Sciences, Kyushu University of Health and Welfare
-
IEIRI Ichiro
Department of Hospital Pharmacy, Faculty of Medicine, Tottori University
-
Oguri K
School Of Pharmaceutical Sciences Kyushu University Of Health And Welfare
-
Ieiri Ichiro
Department Of Clinical Pharmacokinetics Graduate School Of Pharmaceutical Sciences Kyushu University
-
Ishii Kumiko
Laboratory Of Molecular Life Science Graduate School Of Pharmaceutical Sciences Kyushu University
-
Ishii Yukimoto
Department Of Surgery Nihon University School Of Medicine
-
Ishii Y
Laboratory Of Molecular Life Science Graduate School Of Pharmaceutical Sciences Kyushu University
-
YAMADA Hideyuki
Laboratory of Molecular Life Science, Graduate School of Pharmaceutical Sciences, Kyushu University
-
ISHII Yuji
Laboratory of Molecular Life Science, Graduate School of Pharmaceutical Sciences, Kyushu University
-
NISHIO Syunji
Department of Neurosurgery, Graduate School of Medical Sciences, Kyushu University
-
Oguri Kazuta
School Of Pharmaceutical Sciences Kyushu University Of Health And Welfare
-
Oguri K
Faculty Of Pharmaceutical Sciences Kyushu University
-
Oguri K
Kyushu Univ. Fukuoka Jpn
-
Ishii Yuri
Central Research Laboratory Fancl Corporation
-
Ieiri Ichiro
Department Of Hospital Pharmacy Faculty Of Medicine Tottori University
-
Nishio Syunji
Department Of Neurosurgery Graduate School Of Medical Sciences Kyushu University
-
Morioka Takato
Department Of Neurosurgery Neurological Institute Kyushu University
-
Morioka Takato
Department Of Neurosurgery Faculty Of Medicine Kyushu University
-
Yamada Hideyuki
Graduate School Of Pharmaceutical Sciences Kyushu University
-
Yamada H
Faculty Of Pharmaceutical Sciences Kyushu University
-
Yamada H
Graduate School Of Pharmaceutical Sciences Kyushu University
-
Morioka T
Department Of Neurosurgery Graduate School Of Medical Sciences Kyushu University
-
Yoshimura Hidetoshi
Department Of Food And Nutrition Nakamura Gakuen
-
Oguri Kazuta
Faculty Of Pharmaceutical Sciences Kyushu University:(present Address)laboratory Of Safety Assessment Panapharm Laboratories Co. Ltd.:(present Address)department Of Food And Nutrition Nakamura Gakuen College
関連論文
- Piperine, a Pepper Ingredient, Improves the Hepatic Increase in Free Fatty Acids Caused by 2,3,7,8-Tetrachlorodibenzo-p-dioxin
- Maternal exposure to dioxin reduces hypothalamic but not pituitary metabolome in fetal rats : a possible mechanism for a fetus-specific reduction in steroidogenesis
- AN-P33 Development of mammalian factors-free medium for cell culture by using silk protein sericin(Section I Animal and Plant Cell Cultures)
- Preparation of Silk Protein Sericin as Mitogenic Factor for Better Mammalian Cell Culture(CELL AND TISSUE ENGINEERING)
- Distribution of ^C-2,3,7,8-tetrachlorodibenzo-p-dioxin to the brain and peripheral tissues of fetal rats and its comparison with adults
- A Method to Reduce Saline and Heparin in Intraoperative Cerebral Angiography : A Preliminary Report
- ラット肝臓のシトクロムP450(P450)とUDP-グルクロン酸転移酵素(UGT)のタンパク間相互作用 : P450-UGT複合体中でUGTが活性を持つことの証明
- Modulation of UDP-Glucuronosyltransferase 2B7 Function by Cytochrome P450s in Vitro : Differential Effects of CYP1A2, CYP2C9 and CYP3A4(Communications to the Editor)
- ^C-methionine uptake in cerebrovascular disease : A comparison with ^F-FDG PET and ^Tc-HMPAO SPECT
- Polymorphism of MDR1 Gene in healthy Japanese Subjects : A Novel SNP with an Amino Acid Substitution (Glu108Lys)
- Double Lumbosacral Lipomas of the Dorsal and Filar Types Associated With OEIS Complex : Case Report
- Contribution of Angiotensin Converting Enzyme Gene Polymorphism to the Action of Angiotensin II Receptor Antagonist (CS-866)
- Site-Selective Oxidation of Strychnine by Phenobarbital Inducible Cytochrome P-450
- SITE-SELECTIVE OXIDATION OF STRYCHNINE BY PHENOBARBITAL INDUCIBLE CYTOCHROME P-450
- Species Difference in Metabolism of Strychnine with Liver Microsomes of Mice, Rats, Guinea Pigs, Rabbits and Dogs
- METABOLIC FATE OF STRYCHNINE IN VITRO
- 高速度撮影によるレーザー切断現象の研究
- レーザ焼入れに関する研究
- THE PROPERTIES OF UDP-GLUCURONYLTRANSFERASE FOR CANNABINOIDS IN RAT LIVER MICROSOMES
- Reduction of the Toxicity of 2, 3, 7, 8-Tetrachlorodibenzo-p-dioxin in Mice Using an Antiulcer Drug, Geranylgeranylacetone(Toxicology)
- Enhanced Elimination of Theophylline, Phenobarbital and Strychnine from the Bodies of Rats and Mice by Squalane Treatment
- Mechanisms of Stimulated Fecal Excretion of Polychlorinated Aromatic Hydrocarbons in Rats
- IN VIVO METABOLITES OF 3,4,3', 4', -TETRACHLOROBIPHENYL AND THE TOXICOLOGICAL ASSESSMENT IN RATS
- PAPR Reduction for PCC-OFDM Systems Using Neural Phase Rotator
- Liver Proteins that are Sensitive to a Dioxin-Like Toxic Compound, Coplanar Polychiorinated Biphenyl, 3,3',4,4',5-Pentachlorobiphenyl
- Neuroimaging and neuropathology in epilepsy : With special reference to focal epileptogenic abnormalities
- Contribution of subtraction ictal SPECT coregistered to MRI to epilepsy surgery : a multicenter study
- Dubin-Johnson 症候群患者に認めたABCC2遺伝子の部分欠損(exon 7 全域)例
- Attenuation of 2,3,7,8-Tetrachlorodibenzo-p-dioxin Toxicity by Resveratrol: A Comparative Study with Different Routes of Administration
- The Plant Flavonoid, Quercetin, Reduces Some Forms of Dioxin Toxicity by Mechanism Distinct from Aryl Hydrocarbon Receptor Activation, Heat-Shock Protein Induction and Quenching Oxidative Stress
- Effects of dioxins on stress-responsive systems and their relevance to toxicity
- Curcumin Anticipates the Suppressed Body Weight Gain with 2,3,7,8-Tetrachlorodibenzo-p-Dioxin in Mice
- Cytochrome P450 1A1 (CYP1A1) Inhibitor α-Naphthoflavone Interferes with UDP-Glucuronosyltransferase (UGT) Activity in Intact but Not in Permeabilized Hepatic Microsomes from 3-Methylcholanthrene-Treated Rats : Possible Involvement of UGT-P450 Interactions
- The Induction of Hepatic Selenium-Binding Protein by Aryl Hydrocarbon (Ah)-Receptor Ligands in Rats
- Role of the Dioxin-like Toxic Compound Coplanar Polychlorinated Biphenyl, 3, 3', 4, 4', 5-Pentachlorobiphenyl in Reducing Hepatic Alcohol Dehydrogenase Levels in Rats in Vivo
- INDUCTION OF RAT HEPATIC CYTOCHROMES P450 BY TOXIC INGREDIENTS IN PLANTS : LACK OF CORRELATION BETWEEN TOXICITY AND INDUCTIVE ACTIVITY
- EFFECT OF CO-ADMINISTRATION OF INTERFERON INDUCER, POLYRIBOINOSINIC ACID-POLYRIBOCYTIDYLIC ACID, WITH SKF 525-A ON HEPATIC DRUG METABOLIZING ENZYMES OF RATS
- SUPPRESSIVE MECHANISM OF INTERFERON INDUCER, POLYRIBOINOSINIC ACID-POLYRIBOCYTIDYLIC ACID, ON THE INDUCTION OF CYTOCHROME P-450 IN RAT LIVER MICROSOMES
- SUPPRESSIVE EFFECT OF INTERFERON INDUCER, POLYRIBOINOSINIC ACID-POLYRIBOCYTIDYLIC ACID ON INDUCTION OF URIDINE DIPHOSPHATE-GLUCURONYLTRANSFERASES AND MONOOXYGENASES IN LIVER MICROSOMES OF RATS
- EFFECT OF COBALTOUS CHLORIDE-TREATMENT ON DRUG METABOLIZING ENZYMES AND TOXICITES INDUCED BY METHYLCHOLANTHRENE-TYPE PCB
- SUPPRESSION BY INTERFERON INDUCER ON INDUCTION OF MONOOXYGENASES AND UDP-GLUCURONYLTRANSFERASES IN LIVER MICROSOMES OF RATS
- FORMATION OF HIGHLY ANALGESIC MORPHINE-6-GLUCURONIDE FOLLOWING PHYSIOLOGIC CONCENTRATION OF MORPHINE IN HUMAN BRAIN
- 21WA-03-2 Significant Induction of Molecular Chaperones, HSP70, HSP90 and Hop in a Rat Testis Cell by Very Low Level of Dioxins.
- NOVEL COLUMN CHROMATOGRAPHY PROCEDURE FOR THE PURIFICATION OF UDP-GLUCURONYLTRANSFERASES
- 2,3,7,8-Tetrachlorodibenzo-p-dioxin potentially attenuates the gene expression of pituitary gonadotropin β-subunits in a fetal age-specific fashion: a comparative study using cultured pituitaries
- Improvement of Islet Culture with Sericin(CELL AND TISSUE ENGINEERING)
- Cerebral Hyperperfusion Syndrome Associated With Non-convulsive Status Epilepticus Following Superficial Temporal Artery-Middle Cerebral Artery Anastomosis : Case Report
- Pharmacokinetic interaction between pravastatin and olmesartan in relation to SLCO1B1 polymorphism
- Human organic cation transporter (OCT1 and OCT2) gene polymorphisms and therapeutic effects of metformin
- Pharmacogenetic determinants of variability in lipid-lowering response to pravastatin therapy
- Influence of common variants in the pharmacokinetic genes (OATP-C, UGT1A1, and MRP2) on serum bilirubin levels in healthy subjects
- Highly Specific and Convenient Color Reaction for Methylenedioxymethamphetamine and Related Drugs Using Chromotropic Acid. Application as a Drug Screening Test
- A New Screening Method for Amphetamine and Methamphetamine Using Dansyl Chloride Derivatization and Cartridge Fluorescence
- Effects of Long-term Administration of Garcinia cambogia extract on Visceral Fat Accumulation in Humans: A Placebo-controlled Double Blind Trial〔和文〕
- Direct Determination of Trace Nitrogen Dioxide by Atmospheric Pressure lonization Mass Spectrometry (APIMS) without Conversion to Nitric Oxide
- Surgical Treatment of Non-ruptured Giant Occipital Arteriovenous Malformations With Frequent Migraine-Like Headache : Two Case Reports
- The Effects of Genetic Polymorphisms of CYP2C9 and CYP2C19 on Phenytoin Metabolism in Japanese Adult Patients with Epilepsy : Studies in Stereoselective Hydroxylation and Population Pharmacokinetics
- Significant Suppression of Aldolase B, Carbonic Anhydrase III and Alcohol Dehydrogenase in Liver Cytosol of Rats Treated with a Highly Toxic Coplanar PCB (Proceedings of the 22nd Symposium on Toxicology and Environmental Health)
- Effect of Highly Toxic Coplanar PCB on Peroxisomal Enzyme Activity : The Species Difference between Rats and Guinea Pigs (Proceedings of the 20th Symposium on Toxicology and Environmental Health)
- Safety of Garcinia cambogia Extract in Healthy Volunteers : High-Dose Administration Study II
- Safety of Garcinia cambogia Extract in Healthy Men: High-Doses Administration Study I
- No-Observed-Adverse-Effect level (NOAEL) and Sequential-High-Doses Administration Study on Garcinia cambogia Extract in Humans
- Brucine as a Potent Inducer of CYP2B3,the Third Member of the CYP2B Subfamily P450 in Rats
- Acute Purulent Discitis with Epidural Abscess of the Cervical Spine in an Adult : Case Report
- Suppression of Carbonic Anhydrase III mRNA Level by an Aryl Hydrocarbon Receptor Ligand in Primary Cultured Hepatocytes of Rat(Toxicology)
- Metabolism of Drugs of Abuse : Its Contribution to the Toxicity and the Inter-Individual Differences in Drug Sensitivity
- An Improved Method for the Purification and Characterization of a 54 kDa Protein in Rat Liver Which Has Recently Been Identified as a Selenium-Binding Protein
- Effect of Dioxins on Molecular Chaperones HSP70 and HSP90 in Rat Leydig Cells(PROCEEDINGS OF 24TH SYMPOSIUM ON TOXICOLOGY AND ENVIRONMENTAL HEALTH)
- The Role of a Rat Liver Cytosolic 54 kDa Protein That is Inducible by Dioxins(PROCEEDINGS OF 24TH SYMPOSIUM ON TOXICOLOGY AND ENVIRONMENTAL HEALTH)
- The effect of 5-(p-hydroxyphenyl)-5-phenylhydantoin (p-HPPH) enantiomers, major metabolites of phenytoin, on the occurrence of chronic side effects : In vivo and in vitro studies
- Drug interactions of zonisamide with phenytoin and sodium valproate: serum cncentrations and protein binding
- The Effect of Phenytoin Withdrawal on Valproic Acid Free Fraction : A Case Report
- Letters to the Editor
- Monitoring Expression of Cytochrome P450 Genes During Postischemic Rat Liver Reperfusion Using DNA Microarrays
- Primary Pineal Yolk Sac Tumor : Ultrastructural and Immunohistochemical Features : Case Report
- Corpora Amylacea Replace the Hippocampal Pyramidal Cell Layer in a Patient with Temporal Lobe Epilepsy
- Iontophoresis using a local anesthetic for the treatment of pediatric acute herpetic pain
- Study of the Physiological Role of 3,3', 4,4', 5-Pentachlorobiphenyl Inducible 54 kDa Protein in Cytosol of Rat Liver (Proceedings of the 23rd Symposium on Toxicology and Environmental Health)
- DEAMINATION OF AMPHETAMINES BY CYTOCHROMES P450: STUDIES ON SUBSTRATE SPECIFICITY AND REGIOSELECTIVITY WITH MICROSOMES AND PURIFIED CYP2C SUBFAMILY ISOZYMES
- Activation of Morphine Glucuronidation by Fatty Acyl-CoAs and Its Plasticity : A Comparative Study in Humans and Rodents Including Chimeric Mice Carrying Human Liver
- THE MECHANISM OF N-DEMETHYLATION OF METHAMPHETAMINE BY LIVER MICROSOMES : THE ROLE OF FLAVIN CONTAINING MONOOXYGENASE AND CYTOCHROME P-450 SYSTEMS
- Modulation of UDP-Glucuronosyltransferase Activity by Endogenous Compounds
- 2,3,7,8-Tetrachlorodibenzo-p-dioxin potentially attenuates the gene expression of pituitary gonadotropin β-subunits in a fetal age-specific fashion : a comparative study using cultured pituitaries
- Enhancement of Dioxin Toxicity with an Anti-Stress Drug, Carbenoxolone, in Mice
- Glutathione depression by dihydropyrazine derivative
- Induction of Bilirubin UDP-Glucuronyltransferase and P-450 4A Subfamily in Guinea Pigs by Treatment with Coplanar PCB (Proceedings of the 18th Symposium on Toxicology, and Environmental Health)
- Enhancement of Acetaminophen Cytotoxicity in Selenium-binding Protein-overexpressed COS-1 Cells
- Effect of Coplanar PCB on Gluconeogenesis and Lipid Metabolism : Comparison between Rats and Guinea Pigs (Proceedings of the 19th Symposium on Toxicology and Environmental Health)
- SPECIES DIFFERENCE OF UDP-GLUCURONYLTRANSFERASE ISOZYMES IN LIVER MICROSOMES
- Stimulating Effect of Liquid Paraffin and Cholestyramine on Fecal Excretion of 2,3,4,7,8-Pentachlorodibenzofuran in Rats (Proceedings of the 12 th Symposium on Environmental Pollutants and Toxicology) (Regular Presentations)
- UDP-GLUCURONYLTRANSFERASES IN MICE BRAIN AND THE INDUCIBILITY
- B-16 SUBSTRATE SPECIFICITY OF PURIFIED FAD-MONOOXYGENASE TOWARD MORPHINE AND COCAINE CONGENERS
- Effect of Highly Toxic 3,3', 4,4', 5-Pentachlorobiphenyl on the Synthesis of Unsaturated Fatty Acids (Proceedings of the 22nd Symposium on Toxicology and Environmental Health)
- "P-29 The alteration of fatty acid composition on the phospholipid of rat liver by highly toxic 3,3',4,4',5-pentachlorobiphenyl.
- STUDIES ON THE MECHANISM OF N-DEMETHYLATION OF METHAMPHETAMINE WITH PURIFIED ENZYMES
- Dosing Time-Dependency of the Arthritis-Inhibiting Effect of Tacrolimus in Mice
- Inhibition of Morphine Glucuronidation in the Liver Microsomes of Rats and Humans by Monoterpenoid Alcohols
- Possible involvement of glutathione balance disruption in dihydropyrazine-induced cytotoxicity on human hepatoma HepG2 cells
- Association study of genetic polymorphisms of drug transporters, SLCO1B1, SLCO1B3 and ABCC2, in African-Americans, Hispanics and Caucasians and olmesartan exposure
- Predictive performance of Bayesian method in a simulation work: One-compartment open linear model containing an oral route.