No-Observed-Adverse-Effect level (NOAEL) and Sequential-High-Doses Administration Study on Garcinia cambogia Extract in Humans
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概要
- 論文の詳細を見る
(−)-Hydroxycitric acid (HCA), a competitive inhibitor of ATP-citrate lyase, is frequently used in dietary supplements for weight loss in humans, and is the principal acid in the rinds of Garcinia cambogia, a fruit native to Asia. NOAEL (no-observed-adverse-effect level) of G. cambogia extract was determined in the present study and examination was made of adverse effects of high-dose administration to 44 healthy volunteers who had received 4000 mg HCA. No adverse effect was noted in any subjects. NOAEL of G. cambogia extract was estimated as more than 4000 mg HCA. Sequential-high-doses administration study was condusted in subjects who had been given 3000 mg HCA daily for 10 days. Blood samples were used to obtain clinical data before and after treatment. The clinical data were essentially the same for either time. G. cambogia extract at more than 3000 mg HCA may be considered safe for healthy persons.
- 日本油化学会の論文
- 2002-05-01
著者
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Shimasaki Hiroyuki
Department of Health and Nutrition, University of Human Arts and Sciences
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OKUHARA Yasuhide
FANCL Research Institute, FANCL Corporation
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Shimasaki H
Teikyo Univ. School Of Medicine Tokyo Jpn
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SHIGEMATSU Norihiro
Central Research Laboratory, FANCL Co., Ltd.
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Ishii Yukimoto
Department Of Surgery Nihon University School Of Medicine
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Shimasaki Hiroyuki
Department Of Biochemistry Teikyo University School Of Medicine
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Shigematsu Norihiro
Central Research Laboratory Fancl Corporation
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Shigematsu Norihiro
Biosci.textile Technol. Shinshu University
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Ishii Y
Laboratory Of Molecular Life Science Graduate School Of Pharmaceutical Sciences Kyushu University
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Ishii Yuri
Central Research Laboratory Fancl Corporation
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HAYAMIZU Kohsuke
Central laboratory, FANCL Corporation
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KANEKO Izuru
Central laboratory, FANCL Corporation
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SHEN Manzhen
Central laboratory, FANCL Corporation
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SAKAGUCHI Hiroyuki
Central laboratory, FANCL Corporation
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OKUHARA Yasuhide
Central laboratory, FANCL Corporation
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Kaneko Izuru
Central Research Laboratory Fancl Corporation
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Shen Manzhen
Central Research Laboratory Fancl Corporation
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Shimasaki Hiroyuki
帝京大医第一生化
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Shimasaki H
Dep. Of Health And Nutrition Univ. Of Arts And Sciences
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Hayamizu Kohsuke
Central Research Laboratory Fancl Corporation
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SHIGEMATSU Norihiro
Central laboratory, FANCL Corporation
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ISHII Yuri
Central laboratory, FANCL Corporation
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