Effects of α-Linolenic Acid-rich Diacylglycerol on Diet-induced Obesity in Mice
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概要
- 論文の詳細を見る
In the present study, we have investigated the effects on body fat of α-linolenic acid-rich diacylglycerol (ALA-DAG), which is a combination of the 1,3-DAG structure and n-3 fatty acid. C57BL/6J mice were fed diets of high fat and sucrose (30 wt %, 13 wt %, respectively, HF group) without or with ALA-DAG added to 1,2,4 wt % for 4 weeks. We noted significant gains in body weight and visceral fat in the mice in the HF group as compared to a group fed an ordinary diet containing 5 wt % fat (LF group). Addition of ALA-DAG resulted in a significant restraint of both body weight and visceral fat weight gain. Furthermore, addition of ALA-DAG to 2wt% and 4wt% significantly reduced the plasma leptin level. When high fat and sucrose diet was continued for 20 weeks, leptin and insulin levels significantly increased as compared to the LF group in addition to the body weight and body fat gains. By replacing 3 wt% of the lipid in the high fat and sucrose diet with 3 wt% of ALA-DAG, leptin and insulin concentrations significantly decreased in addition to body weight and visceral fat loss. These results indicate the anti-obesity function of ALA-DAG, and also suggest the effectiveness of using ALA-DAG in the prevention and treatment of life-style related diseases in which obesity is a risk factor.
- 日本油化学会の論文
- 2001-09-01
著者
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ITAKURA Hiroshige
Department of Food Science, Ibaraki Christian University, College of Life Science
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Shimasaki Hiroyuki
Department of Health and Nutrition, University of Human Arts and Sciences
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Itakura H
Department Of Food Science Ibaraki Christian University
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Itakura Hiroshige
コカコーラ東京研究開発センター
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Itakura Hiroshige
明治製菓
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Itakura H
Ibaraki Christian Univ. Ibaraki Jpn
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TOKIMITSU Ichiro
Biological Science Laboratories, Kao Corp.
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Itakura H
National Inst. Health And Nutrition Tokyo Jpn
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Hase Tadashi
Health Care Products Research Laboratories No.1 Kao Corporation
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Shimasaki H
Teikyo Univ. School Of Medicine Tokyo Jpn
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川崎 紘一
Life Science Center Faculty Of Pharmaceutical Sciences Kobe Gakuin University
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Itakura Hiroshige
Department Of Food Sciences Ibaraki Christian University
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Itakura Hiroshige
Division Of Clinical Nutrition National Institute Of Health And Nutrition
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MEGURO Shinichi
Biological Science Laboratories, Kao Corporation
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KOMINE Yumiko
Biological Science Laboratories, Kao Corporation
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HASE Tadashi
Biological Science Laboratories, Kao Corporation
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MURASE Takatoshi
Biological Science Laboratories, Kao Corporation
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MIZUNO Tomohito
Biological Science Laboratories, Kao Corporation
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ONIZAWA Kouji
Biological Science Laboratories, Kao Corporation
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KAWASAKI Keiko
Biological Science Laboratories, Kao Corporation
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NAKAGIRI Hideaki
Biological Science Laboratories, Kao Corporation
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Itakura H
Division Of Clinical Nutrition National Institute Of Nutrition And Health
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Itakura Hiroshige
Department Of Food Science Ibaraki Christian University
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Shimasaki Hiroyuki
Department Of Biochemistry Teikyo University School Of Medicine
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Kawasaki Koichi
Department Of Pharmacology Faculty Of Pharmaceutical Sciences Nagasaki University:faculty Of Pharmac
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Tokimitsu Ichiro
Health Care Food Research Laboratories Kao Corporation
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Tokimitsu Ichiro
Biological Science Laboratories Kao Corporation
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Hase Tadashi
Biological Science Laboratories Kao Corporation
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Takase Hideto
Health Care Products Research Laboratories No.1 Kao Corporation
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Onizawa Kouji
Biological Science Laboratories Kao Corporation
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Komine Yumiko
Biological Science Laboratories Kao Corporation
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Komine Yumiko
Japan Aviation Electronics Industry Ltd.
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Shimasaki Hiroyuki
帝京大医第一生化
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Kawasaki Keiko
Biological Science Laboratories Kao Corporation
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Meguro Shinichi
Biological Science Laboratories Kao Corporation
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Shimasaki H
Dep. Of Health And Nutrition Univ. Of Arts And Sciences
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Nakagiri Hideaki
Biological Sci. Laboratories Kao Corp.
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