Acylation of Hydrazides with Acetic Acid and Formic Acid
スポンサーリンク
概要
- 論文の詳細を見る
In peptide synthesis, hydrazides are important intermediates for the azide coupling method. A hydrazide is converted to the corresponding azide in the presence of an acid and a nitrite. When acetic acid(or formic acid)is used as the acid, partial acetylation(or formylation)of the hydrazide occurs as a side reaction. Formylation of the hydrazide is much faster than acetylation. Removal of the formyl group on the hydrazide with hydrazine and hydroxylamine was studied. The rate of deformylation with hydrazine treatment is faster than that with hydroxylamine treatment.
- 公益社団法人日本薬学会の論文
- 2002-01-01
著者
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前田 光子
Life Science Center Faculty Of Pharmaceutical Sciences Kobe Gakuin University
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Smith Timothy
School Of Pharmacy University Of Pacific
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川崎 紘一
Life Science Center Faculty Of Pharmaceutical Sciences Kobe Gakuin University
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Keiko Hojo
Life Science Center Faculty Of Pharmaceutical Sciences Kobe Gakuin University
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Hojo Keiko
Faculty Of Pharmaceutical Sciences Kobe Gakuin University
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Maeda M
Department Of Pharmacology Faculty Of Pharmaceutical Sciences Nagasaki University:faculty Of Pharmac
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Maeda Mitsuko
Faculty Of Pharmaceutical Sciences Kobe Gakuin University
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KAWASAKI Koichi
Faculty of Pharmaceutical Sciences and High Technology Research Center, Kobe Gakuin University
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SMITH Timothy
Thomas J. Long School of Pharmacy and Health Science, University of the Pacific
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Kawasaki Koichi
Department Of Pharmacology Faculty Of Pharmaceutical Sciences Nagasaki University:faculty Of Pharmac
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Kawasaki Keiko
Biological Science Laboratories Kao Corporation
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Hojo Keiko
Faculty Of Pharmaceutical Sciences & Cooperative Research Center Of Life Sciences Kobe Gakuin Un
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Maeda Masatomo
Laboratory Of Biochemistry And Molecular Biology Graduate School Of Pharmaceutical Sciences Osaka Un
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