Mechanism of Liver Tyrosine Aminotransferase Increase in Ethanol-Treated Mice and Its Effect on Serum Tyrosine Level

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概要

• 論文の詳細を見る

• Liver tyrosine aminotransferase (TAT) activity is known to increase with ethanol treatment; however, the mechanism of this increase is unclear. Upon investigation we found that TAT activity and mRNA levels started to increase 2h after ethanol administration and continued to increase until 6h after ethanol administration. The increase in ethanol-induced TAT activity could not be explained by calorie loading after fasting, since ethanol loading increased TAT expression, while glucose loading decreased TAT expression. In addition, liver TAT activity was not related to serum tyrosine levels. TAT activity increased when an adenosine A2 agonist, 5'-N-ethylcarboxamide adenosine, was given. Since TAT activity is increased by cAMP, and ethanol increases cAMP production via an adenosine receptor-dependent mechanism, this increase in ethanol-induced TAT activity may occur via an adenosine receptor-dependent mechanism.

• 日本ビタミン学会の論文

著者

• Matsuda Koichi

  Faculty Of Nutrition Kobe-gakuin University

• Maeda Mitsuko

  Fac. Of Pharmaceutical Sciences Kobe Gakuin Univ.

• Maeda Mitsuko

  Faculty Of Pharmaceutical Sciences Kobe Gakuin University

• KAWASAKI Koichi

  Faculty of Pharmaceutical Sciences and High Technology Research Center, Kobe Gakuin University

• TAMAKI Nanaya

  Faculty of Nutrition, Kobe-Gakuin University

• Fujimoto(SAKATA) Shigeko

  Faculty of Nutrition, Kobe Gakuin University

• FUJINO Mayumi

  Faculty of Nutrition, Kobe Gakuin University

• OHIRA Hideo

  Faculty of Nutrition, Kobe Gakuin University

• Kawasaki Koichi

  Faculty Of Pharmacy Kobe Gakuin University

• Ohira Hideo

  Faculty Of Nutrition Kobe Gakuin University

• Tamaki Nanaya

  Faculty Of Nutrition Kobe-gakuin University

• Fujino Mayumi

  Faculty Of Nutrition Kobe Gakuin University

• FUJIMOTO SAKATA

  Faculty of Nutrition, Kobe-Gakuin University

• Fujimoto(sakata) S

  Faculty Of Nutrition Kobe-gakuin University

• TAMAKI Nanaya

  Faculty of Nutrition and High Technology Research Center, Kobe Gakuin University

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