Effect of Fasting on Methionine Adenosyltransferase Expression and the Methionine Cycle in the Mouse Liver

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概要

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• The effect of fasting on mouse liver methionine adenosyltransferase (MAT I/III) expression and the regulation of methionine metabolism were investigated. The mRNA level, protein level, and activity of MAT I/III were increased by fasting for 10 or 16h. In spite of the increase of MAT I/III activity, S-adenosylmethionine, the product of methionine due to MAT I/III, decreased. S-Adenosylhomocysteine, which is made from S-adenosylmethionine by its coupling to methyltransferase, increased as a result of fasting for 16h. These results suggest that the total methylation reactions using S-adenosylmethionine are stimulated in the fasting mouse liver. However, the DNA methylation level was not changed by fasting for 16h. Glutathione, which is made by the transsulfuration pathway from homocysteine, decreased due to fasting. Regulation of supplementation of S-adenosylmethionine may occur in the fasting mouse because MAT I/III activity increases and the flow to glutathione is decreased.

• 日本ビタミン学会の論文

著者

• Matsuda Koichi

  Faculty Of Nutrition Kobe-gakuin University

• Maeda Mitsuko

  Fac. Of Pharmaceutical Sciences Kobe Gakuin Univ.

• Maeda Mitsuko

  Faculty Of Pharmaceutical Sciences Kobe Gakuin University

• KAWASAKI Koichi

  Faculty of Pharmaceutical Sciences and High Technology Research Center, Kobe Gakuin University

• HORIKAWA Yoko

  Faculty of Nutrition, Kobe-Gakuin University

• SAKATA Shigeko

  Faculty of Nutrition, Kobe-Gakuin University

• TAMAKI Nanaya

  Faculty of Nutrition, Kobe-Gakuin University

• OKUMURA Sonomi

  Faculty of Nutrition, Kobe Gakuin University

• CHOU Janice

  National Institutes of Child Health and Human Development

• Kawasaki Koichi

  Faculty Of Pharmacy Kobe Gakuin University

• Tamaki Nanaya

  Faculty Of Nutrition Kobe-gakuin University

• Okumura Sonomi

  Faculty Of Nutrition Kobe Gakuin University

• FUJIMOTO SAKATA

  Faculty of Nutrition, Kobe-Gakuin University

• Fujimoto(sakata) S

  Faculty Of Nutrition Kobe-gakuin University

• Horikawa Yoko

  Faculty Of Nutrition Kobe-gakuin University

• TAMAKI Nanaya

  Faculty of Nutrition and High Technology Research Center, Kobe Gakuin University

• HORIKAWA Yoko

  Faculty of Nutrition and High Technology Research Center, Kobe Gakuin University

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