Synthesis of Some Pseudo-Peptide Analogs of Thiol Proteinase Inhibitors
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概要
- 論文の詳細を見る
Some pseudo-peptide analogs of thiol proteinase inhibitors were synthesized by a conventional solution method. Among them, Suc-Ala-Val-Val-Ala-Ψ-(CH_2-NH)-Ala-pNA (peptide 1) and Suc-Ala-Val-Val-Ψ-(CH_2-NH)-Ala-Ala-pNA (peptide 2) showed a stronger inhibitory activity compared with parent peptide such as Suc-Ala-Val-Val-Ala-Ala-pNA. In particular, peptide 2 was about 10-fold as active as the parent peptide (IC_<50>=8 μM). Inserting Ψ-(CH_2-NH) possibly makes the inhibitor less susceptible to papain and, as a result, produces more potent inhibition.
- 公益社団法人日本薬学会の論文
- 1999-03-15
著者
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OKADA Yoshio
Faculty of Pharmaceutical Sciences, Kobe Gakuin University
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川崎 紘一
Life Science Center Faculty Of Pharmaceutical Sciences Kobe Gakuin University
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Okada Yoshio
Faculty Of Pharmaceutical Sciences Kobe Gakuin University
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KAWASAKI Koichi
Faculty of Pharmaceutical Sciences and High Technology Research Center, Kobe Gakuin University
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IGUCHI Shin
Faculty of Pharmaceutical Sciences, Kobe Gakuin University
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OKAMOTO Hiroshi
Faculty of Pharmaceutical Sciences, Kobe Gakuin University
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UMEZAWA Chisae
Faculty of Pharmaceutical Sciences, Kobe-Gakuin University
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Kawasaki Koichi
Department Of Pharmacology Faculty Of Pharmaceutical Sciences Nagasaki University:faculty Of Pharmac
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Okamoto H
Faculty Of Pharmacy Meijo University
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Umezawa Chisae
Faculty Of Pharmaceutical Sciences Kobe Gakuin University
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Kawasaki Keiko
Biological Science Laboratories Kao Corporation
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Inoue S
Fujisawa Technical Serv. Co. Ltd. Osaka Jpn
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Okamoto Hiroshi
Faculty Of Engineering Chiba University
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