DEVELOPMENT OF A PLASMA KALLIKREIN SELECTIVE INHIBITOR

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概要

• 論文の詳細を見る
• 公益社団法人日本薬学会の論文

著者

• TSUDA Yuko

  Faculty of Pharmaceutical Sciences, Kobe Gakuin University

• OKADA Yoshio

  Faculty of Pharmaceutical Sciences, Kobe Gakuin University

• Tsuda Yuko

  Faculty Of Pharmaceutical Science Kobe Gakuin University

• Okada Yoshio

  Faculty Of Pharmaceutical Sciences Kobe Gakuin University

• Hijikata-Okunomiya Akiko

  Faculty of Health Science, Kobe University School of Medicine

• Hijikata‐okunomiya A

  Faculty Of Health Science Kobe University School Of Medicine

• Okamoto Shosuke

  Kobe Research Projects On Thrombosis And Haemostatis

• Wanaka Keiko

  Kobe Research Projects On Thrombosis And Haemostatis

• WANAKA Keiko

  Faculty of Pharmaceutical Sciences, Kobe-Gakuin University

• HIJIKATAOKUNOMIYA Akiko

  Faculty of Pharmaceutical Sciences, Kobe-Gakuin University

• OKAMOTO Shosuke

  Faculty of Pharmaceutical Sciences, Kobe-Gakuin University

• 岡本 成羽

  Molecular Chemistry Laboratory Takeda Chemical Industries Ltd.

関連論文

• Synthesis of Endomorphin-2Analogues Containing Piperidinecarboxylic Acid (Pip) and 2-Azetidinecarboxylic Acid (Aze)
• Synthesis and Biological Activity of Endomorphin-2 Analogues Containing Pro Mimics
• Synthesis and Binding Activities of Endomorphin Analogs Containing 1-Aminocyclopropane-1-carboxylic Acid
• Application of a Unique Automated Synthesis System for Solution-phase Peptide Synthesis
• Inhibiton of Thrombin-induced Cartilage Proteoglycan Release by Argatroban
• The Role of the Carboxyl Group of Asp_ of Bovine Pancreatic Ribonuclease A in Enzymatic Activity(Biological Chemistry)
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• Amino Acids and Peptides. LV. Application of 2-Adamantyl Dericatives as Protecting Groups to the Synthesis of Peptide Fragments Related to Sulfolobus solifataricus Ribonuclease. II
• Amino Acids and Peptides. LIV. Application of 2-Adamantyl Derivatives as Protecting Groups to the Synthesis of Peptide Fragments Related to Sulfolobus solifataricus Ribonuclease. I
• Amino Acids and Peptides. LI. Application of the 2-Adamantyloxycarbonyl (2-Adoc) Group to the Protection of the Hydroxyl Function of Tyrosine in Peptide Synthesis
• Differential Receptor Recognition by Dmt-Containing Enkephalin Dimers Cross-Linked by Phenylenediamines
• Deprotection of the Indole (N^)_Formyl (For) Group on Tryptophan Employing a New Reagent, N,N'-Dimethylethylendiamine (DMEDA) in an Aqueous Solution
• Development of μ-Receptor Selective Opioid Mimetics Derived from Endomorphin Sequences
• SYNTHESIS OF EGLIN C AND DEVELOPMENT OF INHIBITORS AGAINST HUMAN LEUKOCYTE ELASTASE AND CATHEPSIN G
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• Synthesis and Bioactivity of Novel Type Pyrazinone Ring-Containing μ-Opioid Ligands
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• The Structure-Activity Relationship of Dmt-NH-X
• Synthesis of New Pyrazinone Ring-Containing Opioid Mimetics and Studies on Their Structure-Activity Relationship
• Stereoselective Synthesis of Unique L-Tyrosine Analogs : Development of Novel μ-Opioid Receptor Ligands
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• Resin Selection Based on the Lability of Peptidyl-Resin Linkage towards HF and TFA Steps : Dependence on the C-Terminal Amino Acid and Peptide Length
• Synthesis of Endomorphin-2 Analogues, Studies on Their Activities for Opioid Receptors, and Three Dimensional Structure
• Synthesis of Pyrazinone Ring-Containing Opioid Mimetics and Examination of Their Opioid Receptor-Binding Activity
• Design and Synthesis of Pyrazinone Ring-Containing Opioid Mimetics and Examination of Their Opioid Receptor-Binding Activity
• Synthesis of Endomorphin Analogs and Studies on the Structure-Opioid Receptor-Binding Activity Relationship
• Amino Acids and Peptides. LII. Design and Synthesis of Opioid Mimetics Containing a Pyrazinone Ring and Examinaiton of Their Opioid Receptor Binding Activity
• Synthesis of Pyrazinone Ring-Containing Tyrosine Derivatives and Examination of Their Binding Activity with Opioid Receptors
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• Synthesis of γ-2-Adamantylglutamate and Its Application to the Peptide Synthesis
• Development of Potent and Selective Plasmin and Plasma Kallikrein Inhibitors and Studies on the Structure-Activity Relationship
• Development of Plasmin Inhibitors and Their Effect on M1(Melanoma) and HT29 Cell Lines
• Preparation of Highly Efficient Resin for Affinity Chromatography Employing Synthetic Specific Inhibitors : Further Studies on Purification of Plasma Kallikrein (PK)
• Development of Plasmin-Selective Inhibitors and Studies of Their Structure-Activity Relationship
• Amino Acids and Peptides. LIII. Synthesis and Biological Activities of Some Pseudo-Peptide Analogs of PKSI-527,a Plasma Kallikrein Selective Inhibitor : The Importance of the Peptide Backbone
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• Purification of Plasma Kallikrein (PK) : Preparation of PK Specific Inhibitor-Polymer Conjugate and Its Application to Purification of PK
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• Synthesis of 2(1H)-Pyrazinone Derivatives from Dipeptides and Its Application to the Development of Proteinase Inhibitor
• DEVELOPMENT OF A PLASMA KALLIKREIN SELECTIVE INHIBITOR
• Structural Studies of [2',6'-Dimethyl-L-tyrosine^1]Endomorphin-2 Analogues Containing Proline Mimics
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• Design of Opioidmimetics : Dimerization of 2', 6'-Dimethyl-L-Tyrosine
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• DEVELOPMENT OF A NEW N^π-PROTECTING GROUP FOR HISTIDINE, N^π-1-ADAMANTYLOXYMETHYLSHISTIDINE
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• Amino Acids and Peptides. XLVI. Introduction of Carboxyl Function into Pyrazinone by Using Newly Developed Procedure for pyrazinone Ring Formation : Observation of Immediate Decarboxylation
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• Inhibitory Effect of Peptide Mimetics Including Naphthyl Group on DNA Polymerase β Activity
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