Development of Plasmin-Selective Inhibitors and Studies of Their Structure-Activity Relationship

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概要

• 論文の詳細を見る

• Various compounds were synthesized by combining three components at positions P_1,P_<1'> and P_<2'>. Of these, N-(trans-4-aminomethylcyclohexanecarbonyl)-Tyr(O-2-bromobenzyloxycarbonyl)-octylamide inhibited plasmin selectively with IC_<50> values of 0.80 and 0.23 μM towards S-2251 and fibrin, respectively. THis compound also inhibited plasma kallikrein, urokinase, thrombin and trypsin with IC_<50> values of 10,>50,>50 and 1.6 μM, rspectively.

• 公益社団法人日本薬学会の論文
• 2000-02-01

著者

• TSUDA Yuko

  Faculty of Pharmaceutical Sciences, Kobe Gakuin University

• OKADA Yoshio

  Faculty of Pharmaceutical Sciences, Kobe Gakuin University

• Yokoi T

  Faculty Of Pharmaceutical Sciences Kobe Gakuin University

• Tsuda Yuko

  Faculty Of Pharmaceutical Sciences Kobe Gakuin University:cooperative Research Center Of Life Scienc

• Tsuda Yuko

  Faculty Of Pharmaceutical Science Kobe Gakuin University

• Okada Yoshio

  Faculty Of Pharmaceutical Sciences Kobe Gakuin University

• Hijikata-Okunomiya Akiko

  Faculty of Health Science, Kobe University School of Medicine

• Okamoto Shosuke

  Kobe Research Projects on Thrombosis and Haemostasis

• Takahashi M

  Research Center For Medicinal Plant Resources National Institute Of Biomedical Innovation

• TADA Mayako

  Faculty of Pharmaceutical Sciences, Kobe Gakuin University

• WANAKA Keiko

  Kobe Research Projects on Thrombosis and Haemostasis

• Hijikata‐okunomiya A

  Faculty Of Health Science Kobe University School Of Medicine

• Hijikata-okunomiya Akiko

  Faculty Of Health Science Kobe University School Of Medicine

• Okamoto Shosuke

  Kobe Research Projects On Thrombosis And Haemostatis

• Wanaka Keiko

  Kobe Research Projects On Thrombosis And Haemostatis

• Tada M

  Faculty Of Pharmaceutical Sciences Kobe Gakuin University

• MATSUMOTO oshikazu

  Faculty of Pharmaceutical Sciences, Kobe Gakuin University

• Tsuda Y

  Faculty Of Pharmaceutical Sciences And High Technology Research Center Kobe Gakuin University

• Matsumoto Oshikazu

  Faculty Of Pharmaceutical Sciences Kobe Gakuin University

• Matsumoto Yoshikazu

  Faculty Of Pharmaceutical Sciences Kobe Gakuin University

• 岡本 成羽

  Molecular Chemistry Laboratory Takeda Chemical Industries Ltd.

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