Deprotection of the Indole (N^<ind>)_Formyl (For) Group on Tryptophan Employing a New Reagent, N,N'-Dimethylethylendiamine (DMEDA) in an Aqueous Solution

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概要

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• The deprotection of the indole (N^<ind>)-formyl (For) group on Trp was achieved in a 95% yield using N,N'-dimethylethylendiamine (DMEDA) (1.5, 2.0, 3.0eq) in water at room temperature. A new reagent was successfully applied to the deprotection of a model peptide, H-Phe-Trp(N^<ind>-For)-Lys-Tyr-OH, to give H-Phe-Trp-Lys-Tyr-OH in a 91% yield.

• 公益社団法人日本薬学会の論文
• 2009-02-01

著者

• TSUDA Yuko

  Faculty of Pharmaceutical Sciences, Kobe Gakuin University

• OKADA Yoshio

  Faculty of Pharmaceutical Sciences, Kobe Gakuin University

• Yokoi T

  Faculty Of Pharmaceutical Sciences Kobe Gakuin University

• Tsuda Yuko

  Faculty Of Pharmaceutical Sciences Kobe Gakuin University:cooperative Research Center Of Life Scienc

• Tsuda Y

  Faculty Of Pharmaceutical Sciences Kobe Gakuin University

• Tsuda Yuko

  Faculty Of Pharmaceutical Science Kobe Gakuin University

• Okada Yoshio

  Faculty Of Pharmaceutical Sciences Kobe Gakuin University

• ODAGAMI Takenao

  Research Institute, PRISM Bio Lab

• KOGAMI Yuji

  Research Institute, PRISM Bio Lab

• KOUJI Hiroyuki

  Research Institute, PRISM Bio Lab

• Kouji Hiroyuki

  Research Institute Prism Bio Lab

• Okada Y

  Faculty Of Pharmaceutical Sciences Kobe Gakuin University

• Kogami Yuji

  Research Institute Prism Bio Lab

• Odagami Takenao

  Research Institute Prism Bio Lab

• Tsuda Y

  Faculty Of Pharmaceutical Sciences And High Technology Research Center Kobe Gakuin University

• Ogino Y

  Teikyo Univ. School Of Medicine Chiba

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