Saponins Isolated from Allium chinense G. DON and Antitumor-promoting Activities of Isoliquiritigenin and Laxogenin from the Sama Drug
スポンサーリンク
概要
- 論文の詳細を見る
Investigation of the Chinese crude drug "Xiebai, " the bulbs of Allium chinense G. DON (Liliaceae), led to the isolation of 2 saponins, xiebai-saponin I (laxogenin 3-O-β-xylopyranosyl (1→4)-[α-arabinopyranosyl (1→6)]-β-glucopyranoside) (1) and laxogenin 3-O-α-arabinopyranosyl (1→6)-β-glucopyranoside (2), and the aglycone, laxogenin (3), together with 2 chalcones, isoliquiritigenin (4) and isoliquiritigenin-4-O-glucoside (5), and β-sitosterol glucoside (6). Compounds 1-5 were tested in vitro for their inhibitory effect on the 12-O-tetradecanoylphorbol-13-acetate (TPA)-stimulated ^<32>Pi-incorporation into phospholipids of HeLa cells. In addition to this, laxogenin (3) was proven to have an antitumor-promoting activity in a two-stage lung carcinogenesis experiment.
- 公益社団法人日本薬学会の論文
- 2000-05-01
著者
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NISHINO Hoyoku
Department of Biochemistry, Kyoto Prefectural University of Medicine
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Shibata Shoji
Laboratory Of Natural Medicinal Materials Minophagen Pharmaceutical Co. Ltd.
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Nishino H
Department Of Biochemistry Kyoto Prefectural University Of Medicine
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Nishino H
Department Of Biochemistry And Molecular Biology Kyoto Prefectural University Of Medicine
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Nishino Hoyoku
Department Of Biochemistry And Molecular Biology Graduate School Of Medical Science Kyoto Prefectura
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Nishino Hoyoku
Kyoto Prefectural University Of Medicine
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BABA Masaki
Department of Natural Medicine and Phytochemistry, Meiji Pharmaceutical University
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OKUYAMA Toru
Department of Natural Medicine and Phytochemistry, Meiji Pharmaceutical University
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OKADA Yoshihito
Department of Natural Medicine and Phytochemistry, Meiji Pharmaceutical University
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OHMURA(Nee Matsuda)
Department of Natural Medicine and Phytochemistry, Meiji Pharmaceutical University
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KISHI Naoki
Department of Natural Medicine and Phytochemistry, Meiji Pharmaceutical University
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PENG Jeng
Department of Phytochemistry, Shenyang Pharmaceutical University
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YAO Shin-Sen
Department of Phytochemistry, Shenyang Pharmaceutical University
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BABA Masaki
明治薬科大学天然薬物学教室
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Baba Masaki
Department Of Natural Medicine And Phytochemistry Meiji Pharmaceutical University
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Okada Y
Faculty Of Pharmaceutical Sciences Kobe Gakuin University
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Shibata S
Laboratory Of Natural Medicinal Materials Minophagen Pharmaceutical Co. Ltd.
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Peng J
Department Of Phytochemistry Shenyang Pharmaceutical University
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Kishi N
Department Of Natural Medicine And Phytochemistry Meiji Pharmaceutical University
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Kishi Naoki
Department Of Chemistry And Institute For Advanced Research Nagoya University
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Yao Shin-sen
Department Of Phytochemistry Shenyang Pharmaceutical University
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Okuyama Toru
Department Of Natural Medicine And Phytochemistry Meiji Pharmaceutical University
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Okuyama T
Department Of Natural Medicine & Phytochemistry Meiji Pharmaceutical University
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OHMURA Masayoshi
Department of Natural Medicine and Phytochemistry, Meiji Pharmaceutical University
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Peng Jeng
Department Of Phytochemistry Shenyang Pharmaceutical University
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Ohmura M
Department Of Natural Medicine And Phytochemistry Meiji Pharmaceutical University
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Okuyama Toru
Meiji Pharmaceutical Univ. Tokyo Jpn
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Okada Yoshihito
Department Of Natural Medicine And Phytochemistry Meiji Pharmaceutical University
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