Anti-tumor Promoting Activities of Isoflavonoids from Wistaria brachybotrys
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概要
- 論文の詳細を見る
Eight minor isoflavonoids (3-10) isolated from the knot of Wistaria brachybotrys were tested for their inhibitory effects on Epstein-Barr virus (EBV) activation induced by the tumor promoter, 12-O-tetradecanoyl-phorbol-13-acetate (TPA), in Raji cells as a primary screening test for anti-tumor-promoters (cancer chemopreventive agents), and all the tested compounds showed inhibitory activity. Of these compounds, pendulone (3) was further examined on the cell cycle of Raji cells, and indicated strong inhibition on the effect of the cell cycle induced by TPA. In addition, the compound showed potent anti-tumor-promoting activity for an in vivo two-stage carcinogenesis test of mouse skin using 7,12-dimethylbenz[a]-anthracene and TPA. Consequently, it suggests that 3 could be a valuable chemopreventive agent in chemical carcinogenesis.
- 公益社団法人日本薬学会の論文
- 1997-08-15
著者
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Kozuka M
Kyoto Pharmaceutical Univ. Kyoto Jpn
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Kim Tae-hoon
Faculty Of Pharmaceutical Sciences Okayama University
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TOKUDA Harukuni
Department of Molecular Biochemistry, Kyoto Prefectural University of Medicine
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NISHINO Hoyoku
Department of Biochemistry, Kyoto Prefectural University of Medicine
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Nishino H
Toho University School Of Pharmaceutical Sciences
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Nishino Hoyoku
Department Of Biochemistry And Molecular Biology Graduate School Of Medical Science Kyoto Prefectura
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NAGAI Masahiro
Faculty of Pharmaceutical Sciences, Hoshi University
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Nagai Masahiro
Faculty Of Pharmaceutical Sciences Hoshi University
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KONOSHIMA Takao
Kyoto Pharmaceutical University
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TOKUDA Harukuni
Kyoto Prefectural University of Medicine
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TAKASAKI Midori
Kyoto Pharmaceutical University
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KOZUKA Mutsuo
Kyoto Pharmaceutical University
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MATSUDA Eriko
Faculty of Pharmaceutical Sciences, Hoshi University
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Machiguchi Takahisa
Faculty Of Science Saitama University
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Tokuda Harukuni
Dep. Of Complementary And Alternative Medicine Clinical R&d Graduate School Of Medical Sci. Kana
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Tokuda Harukuni
Department Of Biochemistry And Molecular Biology Kyoto Prefectural University Of Medicine
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Konoshima T
Kyoto Pharmaceutical University
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Konoshima Takao
Faculty Of Pharmacy Chiba Institute Of Science
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Matsuda Eriko
Faculty Of Pharmaceutical Sciences Hoshi University
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米谷 民雄
Division Of Foods National Institute Of Health Sciences
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Konoshima T
Pharmaceutical Sciences Okayama University Graduate School Of Medicine Dentistry And Pharmaceutical
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Konoshima T
Pharmaceutical Sciences Okayama University Graduate School Of Medicine Dentistry And Pharmaceutical
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Nagai Masahiro
Faculty Of Human Environments Studies The University Of Human Environments
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Konoshima Takao
Pharmaceutical Sciences Okayama University Graduate School Of Medicine Dentistry And Pharmaceutical
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NAGAI Masahiro
Faculty of Human Environment, University of Human Environments
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