Anti-tumor-Promoting Activity of Diterpenes from Excoecaria agallocha
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概要
- 論文の詳細を見る
To search for possible anti-tumor-promoters, we carried out the primary screening of seventeen deterpenes (1-17) isolated from the resinous wood of Excoecaria agallocha (Euphorbiaceae) using an in vitro synergistic assay system. Of these diterpenes, ent-16-hydroxy-3-oxo-13-epi-manoyloxide (5), (13R, 14R)-ent-8α, 13;14,15-diepoxy-13-epi-labda-3β-ol (8) ent-3β-hydroxy-15-beyeren-2-one (10) and ent-15-hydroxy-labda-8(17), 13E-dien-3-one (14) exhibited significant inhibitory effects on Epstein-Barr virus (EBV) activation induced by the tumor promoter, 12-O-tetradecanoylphorbol-13-acetate (TPA). Furthermore, 10 exhibited remarkable anti-tumor-promoting activity in vivo on a two-stage carcinogenesis test of mouse tumor using 7,12-dimethylbenz[a]-anthracene (DMBA) as an in;tiator and TPA as a promoter.
- 公益社団法人日本薬学会の論文
- 1998-09-15
著者
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Kim Tae-hoon
Faculty Of Pharmaceutical Sciences Okayama University
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Kim Tae
Pharmaceutical Sciences Okayama University Graduate School Of Medicine Dentistry And Pharmaceutical
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KONISHI Tenji
Kyoto Pharmaceutical University
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KONOSHIMA Takao
Kyoto Pharmaceutical University
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TOKUDA Harukuni
Kyoto Prefectural University of Medicine
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TAKASAKI Midori
Kyoto Pharmaceutical University
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Takagi Miyuki
Faculty Of Pharmacy Chiba Institute Of Science
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Machiguchi Takahisa
Faculty Of Science Saitama University
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Tokuda Harukuni
Dep. Of Complementary And Alternative Medicine Clinical R&d Graduate School Of Medical Sci. Kana
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Konoshima T
Kyoto Pharmaceutical University
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Konoshima Takao
Faculty Of Pharmacy Chiba Institute Of Science
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KIYOSAWA Shu
Kyoto Pharmaceutical University
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米谷 民雄
Division Of Foods National Institute Of Health Sciences
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Konoshima T
Pharmaceutical Sciences Okayama University Graduate School Of Medicine Dentistry And Pharmaceutical
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Konoshima T
Pharmaceutical Sciences Okayama University Graduate School Of Medicine Dentistry And Pharmaceutical
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Konoshima Takao
Pharmaceutical Sciences Okayama University Graduate School Of Medicine Dentistry And Pharmaceutical
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