Neolignans from Piper futokadsura and Their Inhibition of Nitric Oxide Production
スポンサーリンク
概要
- 論文の詳細を見る
From a MeOH extract of the aerial part of Piper futokadsura, the tetrahydrofuran lignans, futokadsurin A [(7S,8S,7'S,8'R)-3,4,3'-trimethoxy-4'-hydroxy-7,7'-epoxylignan], futokadsurin B [(7R,8R,7'R,8'S)-3,4-dimethoxy-3',4'-methylenedioxy-7,7'-epoxylignan], and futokadsurin C [(7R,8R,7'S,8'S)-3,4-methylenedioxy-3',4'-dimethoxy-7,7'-epoxylignan] were isolated, together with nine known neolignans. In addition, L-tryptophan, pellitorine, phytol, elemicin, and 1,2,4-trimethoxyphenyl-5-aldehyde were isolated. The structures of the new compounds were elucidated using spectroscopic methods. These lignans inhibited nitric oxide production by a murine macrophage-like cell line (RAW 264.7), which was activated by lipopolysaccharide and interferon-γ.
- 公益社団法人日本薬学会の論文
- 2005-01-01
著者
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KONOSHIMA Takao
Faculty of Pharmacy, Chiba Institute of Science
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KITANAKA Susumu
College of Pharmacy, Nihon University
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KONISHI Tenji
Kyoto Pharmaceutical University
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Kitanaka Susumu
College Of Pharmacy Nihon University
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DAIKONYA Akihiro
College of Pharmacy, Nihon University
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Konoshima T
Kyoto Pharmaceutical University
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Konoshima Takao
Faculty Of Pharmacy Chiba Institute Of Science
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Kitanaka S
College Of Pharmacy Nihon University
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Konoshima T
Pharmaceutical Sciences Okayama University Graduate School Of Medicine Dentistry And Pharmaceutical
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Daikonya Akihiro
Res. Unit Of Pharmacognosy School Of Pharmacy Nihon Univ.
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Daikonya Akihiro
College Of Pharmacy Nihon University
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Konoshima T
Pharmaceutical Sciences Okayama University Graduate School Of Medicine Dentistry And Pharmaceutical
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Konoshima Takao
Pharmaceutical Sciences Okayama University Graduate School Of Medicine Dentistry And Pharmaceutical
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