Sesquiterpene Coumarins from Ferula fukanensis and Nitric Oxide Production Inhibitory Effects (2)
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概要
- 論文の詳細を見る
Four new sesquiterpene coumarin derivatives, fukanemarin B (1), fukanefuromarin E (2), fukanefuromarin F (3) and fukanefuromarin G (5) were isolated from a 80% aqueous methanol extract of the roots of Ferula fukanensis. The structures were elucidated based on spectral evidence, especially heteronuclear multiple-bond connectivity (HMBC) and high-resolution MS. The 80% aqueous methanol extract of the roots of Ferula fukanensis (FFE) and the sesquiterpene coumarin derivatives inhibited nitric oxide (NO) production and inducible NO synthase (iNOS) gene expression by a murine macrophage-like cell line (RAW 264.7), which was activated by lipopolysaccharide (LPS) and recombinant mouse interferon-γ (IFN-γ).
- 2004-10-01
著者
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KITANAKA Susumu
College of Pharmacy, Nihon University
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Kitanaka Susumu
College Of Pharmacy Nihon University
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MOTAI Tsunetake
College of Pharmacy, Nihon University
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Motai Tsunetake
日本大学 薬学部
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Motai Tsunetake
College Of Pharmacy Nihon University
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