Inhibitors of Nitric Oxide Production from Hops (Humulus lupulus L.)(Pharmacognosy)
スポンサーリンク
概要
- 論文の詳細を見る
Nitric oxide (NO) plays an important role in many inflammatory responses and is also involved in carcinogenesis. In the present study, we investigated the inhibitory effect of extracts from Humulus lupulus L. on both the production of NO and the expression of inducible NO synthase (iNOS) in mouse macrophage RAW 264.7 cells. The production of NO was induced by a combination of lipopolysaccharide (LPS) and IFN-γ, and determined by Griess assay. The expression of iNOS was detected by Western blotting. The LPS/IFN-γ-induced production of NO and expression of iNOS were significantly inhibited by the ethyl acetate soluble fraction of Humulus lupulus L. Through bioactivity guided fractionation, humulene, five chalcones, 2,2-di-(3-methyl-2-butyleyl)-4,5-dihydoxy- cyclopent-4-en-1,3-dione, lupulone and three of its derivatives were isolated from the ethyl acetate soluble fraction. The chalcones, including xanthohumol, significantly inhibited the production of NO by suppressing the expression of iNOS.
- 公益社団法人日本薬学会の論文
- 2003-01-01
著者
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近藤 恵二
キリンビール(株)基盤技術研究所
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近藤 恵二
キリンビール 基盤技研
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近藤 恵二
キリンビール(株)研究開発部
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近藤 恵二
キリンビール(株)
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Kitanaka Susumu
College Of Pharmacy Nihon University
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Zhao Feng
Central Laboratories For Key Technology Kirin Brewery Co. Ltd.:college Of Pharmacy Nihon University
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KONDO KEIJI
Central Laboratories for Key Technology, Kirin Brewery Co., Ltd.
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Kondo Keiji
Central Laboratories For Frontier Technology Kirin Holdings Co. Ltd.
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Kondo Keiji
Central Laboratories For Key Technology Kirin Brewery Co. Ltd.
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NOZAWA Hajime
Central Laboratories for Key Technology, Kirin Brewery Co., Ltd.
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DAIKONNYA Akihiro
College of Pharmacy, Nihon University
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Nozawa Hajime
Central Laboratories For Key Technology Kirin Brewery Co. Ltd.
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Daikonnya Akihiro
College Of Pharmacy Nihon University
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