Antiallergic Agents from Natural Sources. 3. Structures and Inhibitory Effects on Nitric Oxide Production and Histamine Release of Five Novel Polyacetylene Glucosides from Bidens parviflora WILLD.
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概要
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Five new polyacetylene glucosides, bidensyneosides A_1, A_2, B, C(1-4), and 3-deoxybidensyneoside B(5), have been isolated from the air-dried whole plant of Bidens parviflora WILLD. The structures were identified based on spectroscopic analysis, physicochemical properties, and application of the modified Mosher method to be 3(R), 8(E)-8-decene-4, 6-diyne-1, 3-diol 1-O-β-D-glucopyranoside(1), deca-3(R), 8(Z)8-decene-4, 6-diyne-1, 3-diol 1-O-β-D-glucopyranoside(2), 3(R)-deca-4, 6, 8-triyne-1, 3-diol 1-O-β-D-glucopyranoside(3), 3(R), 8(E)-8-decene-4, 6-diyne-1, 3, 10-triol 1-O-β-D-glucopytranoside(4), and 8(E)-8-decene-4, 6-diyne-1, 10-diol 1-O-β-D-glucopyranoside(5), respectively. These compounds inhibited nitric oxide(NO)production in lipopolysaccharide and interferon-γ activated murine macrophages(RAW264.7)and also inhibited histamine release from rat mast cells stimulated by the antigen-antibody reaction.
- 公益社団法人日本薬学会の論文
- 2001-08-01
著者
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KITANAKA Susumu
College of Pharmacy, Nihon University
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Ishii Rie
中華人民共和国
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Ishii Rie
Saitama Institute Of Public Health
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YAO Xinsheng
Department of Natural Products Chemistry, Shenyang Pharmaceutical
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WANG Naili
Department of Natural Products Chemistry, Shenyang Pharmaceutical University
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Kitanaka Susumu
Res. Unit Of Pharmacognosy School Of Pharmacy Nihon Univ.
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Kitanaka Susumu
College Of Pharmacy Nihon University
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WANG Naili
Life Science Division, Graduate School at Shenzhen, Tsinghua University
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YAO Xinsheng
Life Science Division, Graduate School at Shenzhen, Tsinghua University
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Wang Naili
Life Science Division Graduate School At Shenzhen Tsinghua University
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Yao Xinsheng
Life Science Division Graduate School At Shenzhen Tsinghua University
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Yao Xinsheng
Department Of Natural Products Chemistry 81# Shenyang Pharmaceutical University
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Ishii R
Saitama Institute Of Public Health
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