Six New Andrographolide Metabolites in Rats
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概要
- 論文の詳細を見る
Six new andrographolide metabolites M-5-M-10 were isolated from rat urine, feces, and the contents of the small intestine. Three (M-5-M-7) as sulfate ester compounds were identified as new compounds. The structures of these six metabolites were determined to be 14-deoxy-12(R)-sulfo andrographolide 3-sulfate (M-5), 14-deoxy-12(S)-sulfo andrographolide 3-sulfate (M-6), 14-sulfo isoandrographolide 3-sulfate (M-7), 14-deoxy-11,12-dide-hydroandrographolide (M-8), isoandrographolide (M-9), and 14-deoxy andrographolide (M-10), respectively, based on chemical evidence and spectroscopic analysis.
- 社団法人日本薬学会の論文
- 2003-05-01
著者
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Qiu Feng
Department Of Natural Products Chemistry 81# Shenyang Pharmaceutical University
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Qiu F
Shenyang Pharmaceutical Univ. Shenyang Chn
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Qiu Feng
Department Of Kampo Medicinal Science Hokkaido College Of Pharmacy
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Qiu Feng
Laboratory Of Drug Metabolism And Pharmacokinetics Shenyang Pharmaceutical University
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Gao Hao
Institutes Of Traditional Chinese Medicine And Natural Products Jinan University
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Gao Hao
Department Of Natural Products Chemistry Shenyang Pharmaceutical University
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HE Xiangjiu
Department of Natural Products Chemistry, Shenyang Pharmaceutical University
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LI Jiankuan
Department of Natural Products Chemistry, Shenyang Pharmaceutical University
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CUI Xiangmin
Pan-Pacific Pharmaceutical Company Ltd.
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YAO Xinsheng
Department of Natural Products Chemistry, Shenyang Pharmaceutical
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Li Jiankuan
Department Of Natural Products Chemistry Shenyang Pharmaceutical University
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He Xiangjiu
Department Of Natural Products Chemistry Shenyang Pharmaceutical University
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Yao Xinsheng
Department Of Natural Products Chemistry Shenyang Pharmaceutical
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Yao Xinsheng
Department Of Natural Products Chemistry 81# Shenyang Pharmaceutical University
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