Pharmacological Properties of Traditional Medicines. XXII. Pharmacokinetic Study of Mulberroside A and Its Metabolites in Rat
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概要
- 論文の詳細を見る
To identify the active components in Mori Cortex (Chinese medicine), Mori Cortex extracts were administered orally to rats, and then blood plasma, urine, and bile were analyzed. The results showed only a few remaining metabolites of mulberroside A. Consequently, to clarify the transitional properties of mulberroside A derivatives to tissues and the in vivo abundance ratio of mulberroside A compounds, the pharmacokinetics of mulberroside A derivatives were investigated in this study. When Mori Cortex extracts were administered orally, mulberroside A was only detected in small quantities in the plasma, and its bioavailability was a bout 1%. This is due to the first pass effect, by which most mulberroside A was converted into oxyresveratrol and transported into the circulating blood, and its absorption ratio was estimated at about 50%. Oxyresvertrol was also found to be transported to tissues at high rates. As a result, when analyzing the pharmacological activity of the Mori Cortex in vitro, it is more useful to study oxyresveratarol than mulberroside A.
- 公益社団法人日本薬学会の論文
- 1996-11-15
著者
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Qiu Feng
Department Of Natural Products Chemistry 81# Shenyang Pharmaceutical University
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Qiu F
Shenyang Pharmaceutical Univ. Shenyang Chn
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Qiu Feng
Department Of Kampo Medicinal Science Hokkaido College Of Pharmacy
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Qiu Feng
Laboratory Of Drug Metabolism And Pharmacokinetics Shenyang Pharmaceutical University
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Saito K
Department Of Kampo Medicinal Science Hokkaido College Of Pharmacy
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Kano Yoshihiro
Department Of Kampo Medicinal Science Hokkaido Pharmacutical University
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Kano Y
Department Of Traditional Medicinal Science Hokkaido College Of Pharmacy
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Kano Yoshihiro
Department Of Kampo Medicinal Science Hokkaido College Of Pharmacy
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Yao Xinsheng
Shenyang Pharmaceutical University
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SAITO Ken-ichi
Department of Kampo Medicinal Science, Hokkaido College of Pharmacy
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KOMATSU Ken-ichi
Department of Kampo Medicinal Science, Hokkaido College of Pharmacy
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KAWASAKI Kanako
Department of Kampo Medicinal Science, Hokkaido College of Pharmacy
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Komatsu Ken-ichi
Department Of Kampo Medicinal Science Hokkaido College Of Pharmacy
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Kano Yoshihiro
Department Of Gastroenterological Surgery Osaka University Graduate School Of Medicine
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