Release of Nitric Oxide from a Spin Trap, N-tert-butyl-α-phenylnitrone, under Various Oxidative Conditions

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概要

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• Nitric oxide (NO) generation from a spin trap, N-tert-butyl-α-phenylnitrone (PBN) under various oxidative conditions was examined. The absorbance of PBN at 295 nm decreased with time of UV-irradiation, showing that PBN was decomposed by UV irradiation. The hydroxyl radical formed from a Fenton reagent also decomposed PBN, but there was little effect by a peroxyl radical and a superoxide. Nitrite, an oxidative product of NO, in PBN solution was determined using a NOx analyzer based on Griess reaction. UV-irradiation and the hydroxyl radical also formed nitrite. Direct detection of NO from the sample on reaction with hydroxyl radical was successful using a GC/MS/SIM on the UV-irradiated sample. NO generated in PBN solutions activated guanylate cyclase. From these results, PBN is viewed as a new kind of medicine which acts as an actioxidant and as an No donor in vivo.

• 公益社団法人日本薬学会の論文
• 1998-04-15

著者

• Saito K

  Department Of Kampo Medicinal Science Hokkaido College Of Pharmacy

• 斉藤 謙一

  Department Of Physiology And Anatomy Nihon University College Of Pharmacy

• KAZAMA Shunsuke

  School of Pharmaceutical Sciences, University of Shizuoka

• YOSHIOKA Hisashi

  Institute for Environmental Sciences, University of Shizuoka

• Cutler R

  Nih Md Usa

• Yoshioka H

  Univ. Shizuoka Shizuoka Jpn

• SAITO Kieko

  Gerontology Research Center, National Institute on Aging, NIH

• CUTLER Richard

  Gerontology Research Center, National Institute on Aging, NIH, University of Shizuoka

• Shinozaki Kazuo

  Riken Kanagawa Jpn

• Kazama S

  School Of Pharmaceutical Sciences University Of Shizuoka

• Kazama Shunsuke

  School Of Pharmaceutical Sciences University Of Shizuoka

• Yoshioka Hisashi

  Institute For Environmental Science University Of Shizuoka

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