Sulfated N-Myristoyl Chitosan as a Surface Modifier of Liposomes
スポンサーリンク
概要
- 論文の詳細を見る
Sulfated N-myristoyl chitosan (S-M-chitosan), which is strongly electrolytic and water soluble as well as partly hydrophobic due to long alkyl chains, was synthesized to be used as a liposome-surface modifier. The effects of the treatment with an aqueous S-M-chitosan solution on the stability of the liposome suspension prepared from hydrogenated egg yolk lecithin were examined on several points. A suspension of large liposomes prepared by the Bangham method was precipitated by standing for a day, but the precipitation was restrained when the sample was treated with S-M-chitosan solution. The turbidity of a small liposome suspension Was changed greatly after the suspension was freeze-thawed, but the change was small in the treated sample. A similar result was obtained when the suspension was freeze-dried following the addition of water. These results come from the facts that the surface of the liposome was coated with S-M-chitosan and negatively charged as ascertained by the measurement of zeta potential and the electron microscopic observation. The repulsive force between charges was considered to be the origin of the stabilization. It was also shown from an ESR experiment that the treatment suppressed the elution rate of the material incorporated into the liposomes.
- 社団法人日本農芸化学会の論文
- 1993-07-23
著者
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YOSHIOKA Hisashi
Department of Food and Nutritional Sciences, Graduate School of Nutritional and Environmental Scienc
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TANIZAWA Hisayuki
School of Pharmaceutical Sciences, University of Shizuoka
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YOSHIOKA Hisashi
Institute for Environmental Sciences, University of Shizuoka
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Kamiya Mamoru
Department Of Environmental Science University Of Shizuoka
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Yoshioka H
Univ. Shizuoka Shizuoka Jpn
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TANIZAWA Hisayuki
Department of Human Life Sciences, Hiroshima Jogakuin University
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Hirota Sadao
Department Of Environmental Science And School Of Pharmaceutical Science University Of Shizuoka
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Tanizawa H
School Of Pharmaceutical Sciences University Of Shizuoka
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Kazama S
School Of Pharmaceutical Sciences University Of Shizuoka
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Kamiya M
Department Of Environmental Science University Of Shizuoka
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Kazama Shunsuke
Department of Environmental Science, and School of Pharmaceutical Science, University of Shizuoka
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Tanizawa Hisayuki
Department Of Human Life Sciences Hiroshima Jogakuin University
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Yoshioka Hisashi
Institute For Environmental Science University Of Shizuoka
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Yoshioka Hisashi
Department Of Food And Nutritional Sciences Graduate School Of Nutritional And Environmental Science
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YOSHIOKA Hisashi
Department of Environmental Science, University of Shizuoka
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