Changes in the Mutagenic and Estrogenic Activities of 17β-Estradiol after Treatment with Nitrite
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概要
- 論文の詳細を見る
We determined the changes in the mutagenic and estrogenic activities of 17β-estradiol after a nitrite treatment. Nitrite-treated 17β-estradiol showed mutagenic activities toward Salmonella typhimurium strains TA 100 and TA 98. We confirmed that nitrite-treated 17β-estradiol generated radicals from the results of an analysis of electron spin resonance. By applying an instrumental analysis, we identified 2-nitro-17β-estradiol to have been formed in the reaction mixture. 2-Nitro-17β-estradiol did not exhibit mutagenic activities toward Salmonella typhimurium strains, suggesting that other mutagens might have been formed in the reaction mixture. The clastogenic properties of nitrite-treated 17β-estradiol and 2-nitro-17β-estradiol were analyzed by a micronucleus test with male ICR mice. Nitrite-treated 17β-estradiol and 2-nitro-17β-estradiol induced a significantly higher frequency of micronucleated reticulocytes in mice. The estrogenic activity of 2-nitro-17β-estradiol was found to be lower than that of 17β-estradiol. These data suggest that a daily oral intake of 17β-estradiol and nitrite might induce the formation of mutagenic compounds in our body.
- 社団法人 日本農芸化学会の論文
- 2006-04-23
著者
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KUMAZAWA Shigenori
Department of Food and Nutritional Sciences, and Global COE Program, University of Shizuoka
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OKADA MASAKI
Department of Surgery, School of Medicine, Jichi Medical University
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KAMIHIRA Miya
Department of Life Science, Himeji Institute of Technology, Harima Science Garden City
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Kamihira Miya
Lab. Of Functional Food Sci. And Global Coe Program School Of Food And Nutritional Sciences Univ. Of
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Kamihira Miya
Department Of Food And Nutritional Sciences Graduate School Of Nutritional And Environmental Science
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Okada Masaki
Department Of Ophthalmology Osaka University Graduate School Of Medicine
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Kinae Naohide
Dep. Of Food And Nutritional Sciences Graduate School Of Nutritional And Environmental Sciences And
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Kinae Naohide
Department Of Food And Nutritional Sciences Graduate School Of Nutritional And Environmental Science
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Sugiyama Chitose
School of Health Promotional Science, Hamamatsu University
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Sano Ayako
Department Of Food And Nutritional Sciences Graduate School Of Nutritional And Environmental Science
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Kumazawa Shigenori
Department Of Food And Nutritional Sciences Graduate School Of Nutritional And Environmental Science
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MASUDA Shuichi
Department of Food and Nutritional Sciences, Graduate School of Nutritional and Environmental Scienc
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TERASHIMA Yumeko
Department of Food and Nutritional Sciences, Graduate School of Nutritional and Environmental Scienc
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DEGUCHI Yuya
Department of Food and Nutritional Sciences, Graduate School of Nutritional and Environmental Scienc
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TOYOIZUMI Tomoyasu
Department of Food and Nutritional Sciences, Graduate School of Nutritional and Environmental Scienc
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YOSHIOKA Hisashi
Department of Food and Nutritional Sciences, Graduate School of Nutritional and Environmental Scienc
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TERAO Yoshiyasu
Department of Food and Nutritional Sciences, Graduate School of Nutritional and Environmental Scienc
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増田 修一
Dep. Of Food And Nutritional Sciences Graduate School Of Nutritional And Environmental Sciences And
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Masuda Shuichi
Department Of Biological Science Faculty Of Science Hiroshima University
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Terashima Yumeko
Department Of Food And Nutritional Sciences Graduate School Of Nutritional And Environmental Science
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Terashima Yumeko
Department Of Food And Nutritional Sciences Graduate School Of Nutritional And Environmental Science
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Sugiyama Chitose
School Of Health Promotional Science Hamamatsu University
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Kinae Naohide
Department Of Food And Nutritional Sciences Graduate School Of Nutritional And Environmental Science
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Kumazawa Shigenori
Department Of Food And Nutritional Sciences And Global Coe Program University Of Shizuoka
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Terao Yoshiyasu
Department Of Food And Nutritional Sciences Graduate School Of Nutritional And Environmental Science
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Deguchi Yuya
Department Of Food And Nutritional Sciences Graduate School Of Nutritional And Environmental Science
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Toyoizumi Tomoyasu
Department Of Food And Nutritional Sciences Graduate School Of Nutritional And Environmental Science
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Yoshioka Hisashi
Department Of Food And Nutritional Sciences Graduate School Of Nutritional And Environmental Science
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Okada Masaki
Department Mechanical Engineering Kansai University
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Okada Masaki
Department Of Food And Nutritional Sciences Graduate School Of Nutritional And Environmental Science
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YOSHIOKA Hisashi
Department of Environmental Science, University of Shizuoka
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