Effect of Psychologic Stress on Peroxidase and Thiocyanate Levels in Human Saliva Detected by Ultraweak Chemiluminescence
スポンサーリンク
概要
- 論文の詳細を見る
Saliva sampling has the advantage of being noninvasive and stress free. Based on a recent study, salivary ultraweak chemiluminescence (UCL) is a new biomarker of psychologic stress. However, it is not clear what causes changes in the UCL level and whether the change is biologically significant. We investigated the candidates for salivary UCL induced by psychological stressors and discuss the physiologic function of these candidates. Volunteers completed a questionnaire and then performed the Kraepelin test. Saliva was sampled just before, immediately after, and 30 min after the stress exposure. The UCL of saliva significantly increased just after stress exposure (1.56-fold) and returned to prestress levels after 30 min. The concentration of secretory immunoglobulin A also increased significantly and the change in both biomarkers was rapid. Similar significant changes were observed in salivary peroxidase activity and the concentration of thiocyanate (SCN^-). On the other hand, the levels of amylase activity did not significantly increase and the concentration of cortisol increased slowly. Moreover, in the reconstitution experiment, UCL was generated at the same level by a mixture of peroxidase and SCN^- at physiologic concentrations. In conclusion, we determined that the Kraepelin test as a mental arithmetic task elicited a significant response in the body and this response can be calculated using salivary UCL. Furthermore, SCN^- and peroxidase in the saliva play a key role in salivary UCL.
- 公益社団法人日本薬学会の論文
- 2007-04-01
著者
-
ONO Takahiko
Department of Nephrology, Shizuoka General Hospital
-
HIRAMATSU MITSUO
Hamamatsu Photonics K.K.
-
Kinae Naohide
Dep. Of Food And Nutritional Sciences Graduate School Of Nutritional And Environmental Sciences And
-
Kinae Naohide
Department Of Food And Nutritional Sciences Graduate School Of Nutritional And Environmental Science
-
HARADA Hitoshi
Department of Molecular Chemistry, Graduate School of Engineering, Osaka University
-
TERASHIMA Yumeko
Department of Food and Nutritional Sciences, Graduate School of Nutritional and Environmental Scienc
-
Ono Takahiko
Department Of Environmental Biochemistry School Of Pharmaceutical Science University Of Shizuoka
-
Ono Takahiko
Department Of Cardiovascular Medicine Kyoto University Graduate School Of Medicine
-
GOI Nobuhiro
Department of Environmental Biochemistry and Toxicology, University of Shizuoka School of Pharmaceut
-
HIRAI Yuuko
Department of Environmental Biochemistry and Toxicology, University of Shizuoka School of Pharmaceut
-
IKARI Akira
Department of Environmental Biochemistry and Toxicology, University of Shizuoka School of Pharmaceut
-
NAKAMURA Kimitsugu
Hamamatsu Photonics K.K. Electron Tube Division
-
TAKAGI Kuniaki
Department of Environmental Biochemistry and Toxicology, University of Shizuoka School of Pharmaceut
-
Terashima Yumeko
Department Of Food And Nutritional Sciences Graduate School Of Nutritional And Environmental Science
-
Terashima Yumeko
Department Of Food And Nutritional Sciences Graduate School Of Nutritional And Environmental Science
-
Hirai Yuuko
Department Of Environmental Biochemistry School Of Pharmaceutical Science University Of Shizuoka
-
Ikari Akira
Department Of Environmental Biochemistry School Of Pharmaceutical Science University Of Shizuoka
-
Ikari Akira
Department Of Environmental Biochemistry And Toxicology University Of Shizuoka School Of Pharmaceuti
-
Goi Nobuhiro
Department Of Environmental Biochemistry School Of Pharmaceutical Science University Of Shizuoka
-
Takagi Kuniaki
Department Of Environmental Biochemistry And Toxicology School Of Pharmaceutical Science University
-
Harada Hitoshi
Department Of Environmental Biochemistry School Of Pharmaceutical Science University Of Shizuoka
-
Harada Hitoshi
Department Of Electronics And Communication Engineering School Of Science And Engineering Waseda Uni
-
Kinae Naohide
Department Of Food And Nutritional Sciences Graduate School Of Nutritional And Environmental Science
-
Hiramatsu Mitsuo
Hamamatsu Photonics K.k. Central Research Laboratory
関連論文
- Oxalate nephropathy with a granulomatous lesion due to excessive intake of peanuts
- Automated Bedside Measurement of Penile Blood Flow Using Pulse-Volume Plethysmography
- Is There Hemodynamic Rationale for Use of Cuffed Type Anastomosis for Femoro-popliteal Bypass?
- Superficial Thrombophlebitis of the Lower Limbs in Patients with Varicose Veins
- Effect of a portal venous stent for gastrointestinal hemorrhage from jejunal varices caused by portal hypertension after pancreatoduodenectomy
- Clinical Relationship Between Femoral Artery Aneurysms and Arteriomegaly
- Gastrojejunocolic Fistula After Gastrectomy with Billroth II Reconstruction : Report of a Case
- Revascularization to Prevent Postoperative Bowel Infarction After Surgery for Acute Superior Mesenteric Artery Thromboembolism
- Optical diagnosis of gastric cancer using near-infrared multichannel Raman spectroscopy with a 1064-nm excitation wavelength
- Hepatocellular Carcinoma Associated with Lupoid Hepatitis : A Review of Japanese Reports
- Glomerulonephritis induced by methicillin-resistant Staphylococcus aureus infection that progressed during puerperal period
- Amphiphilic Cyclodextrins as Novel Monosaccharide Transport Carriers through a Bulk Liquid Membrane
- Effect of Green Tea on the Formation of Nitrosamines, and Cancer Mortality
- Changes in the Mutagenic and Estrogenic Activities of 17β-Estradiol after Treatment with Nitrite
- Suppressive effects of Sairei-to on mesangial proliferation in a rat model of glomerulonephritis
- COMPARISON OF PEROXIDASE RESPONSE TO MENTAL ARITHMETIC STRESS IN SALIVA OF SMOKERS AND NON-SMOKERS
- Effect of Psychologic Stress on Peroxidase and Thiocyanate Levels in Human Saliva Detected by Ultraweak Chemiluminescence
- Re-biopsy in a patient with IgA nephropathy showing success of treatment with cyclosporin A and angiotensin-II receptor blocker
- Direct effects of simvastatin on proliferation and matrix accumulation in cultured murine mesangial cells
- Suppressive Effects of Perilla frutescens on Mesangioproliferative Glomerulonephritis in Rats
- Expression of Recombinant Antibody against Cancer-Specific Carbohydrate
- Is Rabbit CLCA1 Related to the Basolateral Ca^-Dependent Cl^- Channel of Gastric Parietal Cells?
- Mobilization of Intracellular Ca^ by Thromboxane A_2 Does Not Affect Ca^-Activated K^+ Channels in Rat Colonic Crypt Cells
- Prostaglandin E_2-Activated Housekeeping Cl^- Channels in the Basolateral Membrane of Rat Gastric Parietal Cells
- Genotoxicity and Estrogenic Activity of 3,3′-Dinitrobisphenol A in Goldfish
- Hepatic Angiomyolipoma Developing During the Follow-Up of Ulcerative Colitis : Report of a Case and Review of the Literature
- Second cancer during long-term survival after resection of biliary tract carcinoma
- Dysfunction of Paracellin-1 by Dephosphorylation in Dahl Salt-Sensitive Hypertensive Rats
- Roles of Coagulation Pathway and Factor Xa in the Progression of Diabetic Nephropathy in db/db Mice
- Molecular Mechanism of Inhibition by Lithium of Neuronal Differentiation of Rat PC12 Pheochromocytoma Cells (Proceedings of the 20th Symposium on Toxicology and Environmental Health)
- Lead Inhibits Nitric Oxide Production Transiently by mRNA Level in Murine Macrophage Cell Lines
- Suppression of Cytokine Production in T Helper Type 2 Cells by Nitric Oxide in Comparison with T Helper Type 1 Cells
- Leaf Extract of Wasabia japonica Relieved Oxidative Stress Induced by Helicobacter pylori Infection and Stress Loading in Mongolian Gerbils
- Leaf Extract of Wasabia japonica Relieved Oxidative Stress Induced by Helicobacter pylori Infection and Stress Loading in Mongolian Gerbils
- Effect of Lithium on Neuronal Differentiation by Nerve Growth Factor (NGF) in PC12 Cells (Proceedings of the 19th Symposium on Toxicology and Environmental Health)
- Genotoxicity and Estrogenic Activity of 3,3'-Dinitrobisphenol A in Goldfish
- Impact of In Vivo Ranges of the Variances in the Flow Velocity Waveforms and Flow Split Ratio on the Hemodynamic Effects of the Anastomotic Cuff at Distal End-to-Side Anastomosis
- Isolation of Mutagenic β-Carboline Derivatives after Nitrite Treatment of Maillard Reaction Mixtures and Analysis of These Compounds from Foodstuffs and Human Urine
- Assessment of Renal Toxicity by Transepithelial Transport Activity in Cultured Renal Epithelial Cells (Proceedings of the 21st Symposium on Toxicology and Environmental Health)
- New Subhierarchies of the KP Hierarchy in the Sato Theory.I.Analysis of the Burgers-Hopf Hierarchy by Sato Theory
- A New Approach to Completely Integrable Partial Differential Equations by Means of the Singularity Analysis
- Expression of GFP-Tagged Low Affinity Na^+ -Dependent Glucosa Transporter in Xenopus Oocytes and CHO Cells
- Churg-Strauss syndrome with severe granulomatous angiitis and crescentic glomerulonephritis, which developed during therapy with a leukotriene receptor antagonist
- Serial renal biopsy findings in a case of POEMS syndrome with recurrent acute renal failure
- New Subhierarchies of the KP Hierarchy in the Sato Theory.II.Truncation of the KP Hierarchy
- Anti-hypertensive effects of shichimotsukokato in 5/6 nephrectomized Wistar rats mediated by the DDAH-ADMA-NO pathway