Leaf Extract of Wasabia japonica Relieved Oxidative Stress Induced by Helicobacter pylori Infection and Stress Loading in Mongolian Gerbils
スポンサーリンク
概要
- 論文の詳細を見る
Infection with Helicobacter pylori (H. pylori) can induce gastric disorders, and though its presence cannot explain disease pathogenesis and does not have associations with other factors, it is well known that H. pylori infection causes stomach inflammation following oxidative stress. We examined the suppressive effects of a leaf extract of Wasabia japonica on H. pylori infection and on stress loading in Mongolian gerbils. Following oral administration of wasabi extract of 50 and 200 mg/kg B.W./d for 10 d, the animals were exposed to restraint stress for 90 and 270 min. As for the results, the level of 8-oxo-7,8-dihydro-2′-deoxyguanosine (8-oxodG) in the stomach and oxidative DNA damage in peripheral erythrocytes at 270 min significantly increased. That elevation was significantly suppressed by the addition of the leaf extract. We concluded that the simultaneous loading of H. pylori infection and physical stress loading might induce oxidative DNA damage additively, while a leaf extract attenuated this DNA damage in the stomach as well as the peripheral erythrocytes.
- 社団法人 日本農芸化学会の論文
著者
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MASUDA Hideki
Department of Applied Chemistry, Nagoya Institute of Technology
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Kinae Naohide
Department Of Food And Nutritional Sciences Graduate School Of Nutritional And Environmental Science
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MASUDA Shuichi
Department of Food and Nutritional Sciences, Graduate School of Nutritional and Environmental Scienc
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DEGUCHI Yuya
Department of Food and Nutritional Sciences, Graduate School of Nutritional and Environmental Scienc
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TOYOIZUMI Tomoyasu
Department of Food and Nutritional Sciences, Graduate School of Nutritional and Environmental Scienc
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TAKABAYASHI Fumiyo
University of Shizuoka, Junior College
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SEKIGUCHI Hirotaka
Department of Food and Nutritional Sciences, Graduate School of Nutritional and Environmental Scienc
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