Suppressive Effects of Perilla frutescens on Mesangioproliferative Glomerulonephritis in Rats
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概要
- 論文の詳細を見る
Leaves of Perilla frutescens var. crispa DECNE. (perilla, Labiatae) are used as a garnishing vegetable in East Asian countries as well as an herbal medicine prescribed in Kampo medicines such as Saiboku-to. A previous in vitro study revealed that a decoction of perilla leaves inhibits the proliferation of murine-cultured mesangial cells. In the present study, we evaluated the in vivo anti-proliferative effects of a perilla decoction using rat mesangioproliferative glomerulonephritis induced by an intravenous injection of rabbit anti-rat thymocyte serum (ATS). Leaves of perilla were boiled, and the decoction was orally administered to the rats as drinking water at doses of 100 and 500 mg/kg/d from the day of ATS-injection (day 0) to day 8, when rats were sacrificed. In the histological evaluation, the total number of glomerular cells, proliferating cell nuclear antigen (PCNA) positive cells, and macrophage/monocyte antigen-positive cells in the glomerulus, was significantly decreased in perilla-treated rats. A significantly lower level of proliferation was induced by the serum of the perilla-treated rats than by that of the controls. These results suggest that the perilla decoction suppresses the proliferation of mesangial cells in vivo by an inhibition of the glomerular infiltration of macrophage/monocytes and of the production of circulating growth factors.
- 公益社団法人日本薬学会の論文
- 2001-02-01
著者
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Noda Takashi
国立循環器病センター 心臓血管内科
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Nakajima T
National Center For Child Health And Dev. Tokyo Jpn
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Nakajima Toshiharu
国立医薬品食品衛生研究所
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HONDA Gisho
Department of Pharmaceutical Health Care, Faculty of Pharmaceutical Sciences, Himeji Dokkyo Universi
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ONO Takahiko
Department of Nephrology, Shizuoka General Hospital
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Muso E
Department Of Nephrology And Cardiovascular Medicine Kyoto University Graduate School Of Medicine
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Muso Eri
Division Of Nephrology The Tazuke Kofukai Medical Research Institute Kitano Hospital
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Muso Eri
北野病院 脳神経外科
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Muso Eri
Department Of Nephrology & Dialysis Kitano Hospital
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Nakamura Tomoko
Department of Biology, Physics and Informatics, Faculty of Science, Yamaguchi University
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ONO Takahiko
Division of Molecular Medicine, University of Shizuoka School of Pharmaceutical Sciences
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MAKINO Toshiaki
Department of Kampo Medicinal Science, Hokkaido College of Pharmacy
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Muso Eri
Department Of Internal Medicine Graduate School Of Medicine Kyoto University
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Muso Eri
Department Of Cardiovascular Medicine Faculty Of Medicine Kyoto University Graduate School Of Medici
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Ono Takahiko
Division Of Molecular Medicine University Of Shizuoka School Of Pharmaceutical Sciences
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Ono Takahiko
Department Of Cardiovascular Medicine Kyoto University Graduate School Of Medicine
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Nakamura T
Department Of Allergy And Immunology National Research Institute For Child Health And Development Na
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Honda G
Department Of Pharmacognosy Graduate School Of Pharmaceutical Sciences Kyoto University
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Honda Gisho
Department Of Pharmaceutical Health Care Faculty Of Pharmaceutical Sciences Himeji Dokkyo University
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Muso E
Department Of Nephrology And Dialysis The Tazuke Kofukai Medical Research Institute Kitano Hospital
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Makino T
Dep. Of Pharmacognosy Graduate School Of Pharmaceutical Sci. Nagoya City Univ.
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Makino Toshiaki
Department Of Kampo Medicinal Science Hokkaido College Of Pharmacy
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Makino Toshiaki
Department Of Chemistry Faculty Of Science Okayam University Of Science
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Nakamura Tomoko
Department of Allergy and Immunology, National Research Institute for Child Health and Development, National Center for Child Health and Development
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