Lead Inhibits Nitric Oxide Production Transiently by mRNA Level in Murine Macrophage Cell Lines
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概要
- 論文の詳細を見る
Lead inhibited the production of nitric oxide (NO) in cytokine-induced macrophage cell lines of RAW264 and Mm1. The decrease was revealed in the concentration of lead (0.1-10 μg/ml) which did not decrease the viability of these cells. The inhibition was proved to be due to the suppression of an inducible type of NO synthase (iNOS) mRNA expression in RAW264 cells. This suppression was found at 24 h and then recovered to the control level (stimulated with cytokine alone) following culture. In the RAW264 cell line, the time course pattern of NO production corresponded to the iNOS mRNA expression. From these results, the inhibition of NO production by, at least in part, mRNA level could be implicated in lead-caused abnormalities in immune functions.
- 公益社団法人日本薬学会の論文
- 1996-07-15
著者
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TAKAGI Kuniaki
Department of Environmental Biochemistry and Toxicology, University of Shizuoka School of Pharmaceut
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SUKETA YASUNOBU
Department of Environmental Biochemistry, University of Shizuoka School of Pharmaceutical Science
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Masuda Naoko
Department Of Biology Tokyo Metropolitan University
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Masuda Naoko
Department Of Environmental Biochemistry And Toxicology School Of Pharmaceutical Science University
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Takagi Kuniaki
Department Of Environmental Biochemistry And Toxicology School Of Pharmaceutical Science University
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KANEMATSU Masahiro
Department of Environmental Biochemistry and Toxicology, School of Pharmaceutical Science, Universit
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Suketa Yasunobu
Department Of Environmental Biochemistry And Toxicology School Of Pharmaceutical Science University
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Kanematsu M
Department Of Environmental Biochemistry And Toxicology School Of Pharmaceutical Science University
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