Alteration in Bone Metabolism with Increasing Age : Effects of Zinc and Vitamin D_3 in Aged Rats
スポンサーリンク
概要
- 論文の詳細を見る
The alteration in bone metabolism with increasing age was investigated in the femoral diaphysis of male rats. Calcium content was highest in the bone from 3-week-old rats (491±13 mg/g bone ash), falling gradually with aged to 357±7 and 306±9 mg/g bone ash in 28- and 52-week-old rats, respectively. Bone zinc content increased until rats were 3 weeks of age, and thereafter remained constant. Deoxyribonucleic acid (DNA) content was highest in the bone from 1-week-old rats, and it decreased markedly with increasing age. Alkaline phosphatase and acid phoshatase activities increased up to 3 weeks, then subsequently declined with age. Thus, the retardation of bone metabolism was induced by ageing. When zinc sulfate (5.0,10.0 and 20.0 mg Zn/kg body weight) was administered orally for 3 d to 28-week-old rats, alkaline phosphatase activity and calcium content in the femoral diaphysis was elevated markedly by all doses. The oral administration of vitamin D_3 (2.0 and 20 μg/kg) for 3 d in 28-week-old rats did not produce an appreciable increase in bone alkaline phosphatase activity or calcium content, while 1,25-dihydroxyvitamin D_3 (1.5 μg/kg) caused a significant increase in those biochemical indices. These results indicate that zinc and 1,25-dihydroxyvitamin D_3 play a role as activators in bone metabolism of ageing rats.
- 公益社団法人日本薬学会の論文
著者
-
Yamaguchi Masayoshi
Department Of Environmental Biochemistry Shizuoka College Of Pharmacy
-
Suketa Yasunobu
Department Of Environmental Biochemistry And Toxicology School Of Pharmaceutical Sciences University
-
Suketa Yasunobu
Department Of Environmental Biochemistry And Toxicology School Of Pharmaceutical Science University
-
OZAKI Kayoko
Department of Environmental Biochemistry and Toxicology, School of Pharmaceutical Sciences, Universi
-
Yamaguchi Masayoshi
Department Of Electrical Engineering Nagaoka University Of Technology
-
Yamaguchi Masayoshi
Department Of Environmental Biochemistry And Toxicology School Of Pharmaceutical Sciences University
-
Ozaki Kayoko
Department Of Environmental Biochemistry And Toxicology School Of Pharmaceutical Sciences University
関連論文
- Standard weight of the normal brain, spleen and pancreas in Japanese
- Autopsy Cases of Giant Heart during the Past Ten Years in Osaka(1985-1994)
- Estimation of Age from Soft X-ray Findings of Japanese Females Thyroid Cartilages
- Estimation of Age from Image Processing of Soft X-ray Findings in Japanese Male Thyroid Cartilages
- Sexual discrimination on the soft X-ray findings of Japanese thyreoideal cartilages
- Changes in chromium concentration in organs of Japanese
- Changes in human liver weight in forensic autopsy cases between 1962 and 1992
- Effect of Growth Temperature on the Response of Cells to Mating Hormones in Saccharomyces Cerevisiae
- Expression of Recombinant Antibody against Cancer-Specific Carbohydrate
- STIMULATORY EFFECT OF ZINC ON BONE GROWTH IN WEANLING RATS
- STIMULATION OF BONE RESORPTION BY COMPARATIVELY HIGH DOSE OF ZINC IN RATS
- STIMULATIVE EFFECTS OF CORTISOL AND TESTOSTERONE ON BILE CALCIUM EXCRETION IN THYROPARATHYROIDECTOMIZED RATS
- INTERACTION OF CALCITONIN AND HISTAMINE ON BILE CALCIUM EXCRETION IN THYROPARATHYROIDECTOMIZED RATS
- EFFECT OF FLUORIDE ON PHYSIOLOGICAL ION MOBILIZATIONS IN RATS
- Structure and Non-Equilibrium Phase Diagram of the Co-Sputtered and Post-Annealed Fe-ZnO System
- Stimulatory Effect of Calcitonin on Bone Formation in Tissue Culture
- THE STIMULATORY ROLE OF ZINC IN BONE METABOLISM OF WEANLING RATS
- Molecular Mechanism of Inhibition by Lithium of Neuronal Differentiation of Rat PC12 Pheochromocytoma Cells (Proceedings of the 20th Symposium on Toxicology and Environmental Health)
- Lead Inhibits Nitric Oxide Production Transiently by mRNA Level in Murine Macrophage Cell Lines
- Suppression of Cytokine Production in T Helper Type 2 Cells by Nitric Oxide in Comparison with T Helper Type 1 Cells
- Trinuclear Complexes Containing Incomplete Cubane Co^_3O_4 Cores. Structures of the Isomers of the N-(2-Pyridylmethyl)glycinato Complex
- Effect of Lithium on Neuronal Differentiation by Nerve Growth Factor (NGF) in PC12 Cells (Proceedings of the 19th Symposium on Toxicology and Environmental Health)
- 116. Fundamental Studies on Mechanism of Toxic Action by Tin. : Correlation Between the Accumulated Calcium in Kidney and the Decreased Calcium in Serum, Part II. (The Second Meeting for the Study of Toxic Effect)
- 115. Fundamental Studies on Mechanism of Toxic Action by Tin. : Accumulation of Calcium in Kidney, Part I. (The Second Meeting for the Study of Toxic Effect)
- INHIBITION OF COLLAGEN SYNTHESIS IN THE FEMUR OF RATS ORALLY ADMINISTERED STANNOUS CHLORIDE
- CHANGES OF MINERAL COMPOSITION AND ITS RELATED ENZYME ACTIVITY IN THE FEMUR OF RATS ORALLY ADMINISTERED STANNOUS CHLORIDE
- ACTION OF INORGANIC TIN ON BONE METABOLISM IN RATS : DECREASES IN CALCIUM CONTENT AND PHOSPHATASE ACTIVITY
- Assessment of Renal Toxicity by Transepithelial Transport Activity in Cultured Renal Epithelial Cells (Proceedings of the 21st Symposium on Toxicology and Environmental Health)
- Synthetic [Asu1, 7] Eel Calcitonin Increases Phosphorus Content in the Hepatic Bile of Intact and Nephrectomized Rats
- POSSIBLE MECHANISM OF TIN TO DECREASE CALCIUM CONTENT IN THE FEMUR OF RATS (The 6th Meeting for the Study of Toxic Effect)
- TARGET ORGAN OF INORGANIC TIN AND ITS NO-EFFECT LEVEL IN RATS
- HYPOCALCEMIC EFFECT OF ZINC AND ITS MECHANISM IN RATS
- CALCITONIN AND HEPATIC GLUCOSE OUTPUT : ROLE OF CELLULAR CALCIUM
- The Action of Zinc on Calcium Metabolism and Its Mechanism in Rats (Regular Presentations) (Proceedings of the 9th Symposium on Environmental Pollutants and Toxicology)
- EFFECT OF ZINC ON THE MITOCHONDRIAL FUNCTION IN THE LIVER OF RATS
- Alteration of Sodium Balance Following Administrations of Lead and/or Ethanol to Rats (Regular Presentations) (Proceedings of the 10 th Symposium on Environmental Pollutants and Toxicology)
- FUNDAMENTAI STUDIES ON MECHANISM OF TOXIC ACTION BY TIN. INCREASE OF BILE CALCIUM. PART VI (The Fourth Meeting for the Study of Toxic Effect)
- 225. FUNDAMENTAL STUDIES ON MECHANISM OF TOXIC ACTION BY TIN. DECREASE OF GASTRIC SECRETION. PART IV (The Third Meeting for the Study of Toxic Effect)
- ACTION OF TIN ON CALCIUM METABOLISN IN ENTEROHEPATIC SYSTEM (The 5th Meeting for the Study of Toxic Effect)
- Alteration in Bone Metabolism with Increasing Age : Effects of Zinc and Vitamin D_3 in Aged Rats
- Expression of GFP-Tagged Low Affinity Na^+ -Dependent Glucosa Transporter in Xenopus Oocytes and CHO Cells
- Effects of Calcitonin and Other Hormones on Bile Calcium Excretion in Thyroparathyroidectomized Rats
- Reversible Effect of Calcium-Binding Protein on the Ca^-Induced Activation of Succinate Dehydrogenase in Rat Liver Mitochondoria(Biological)
- Effect of Calcitonin on Ca-ATPase Activity of Plasma Membrane in Liver of Rats
- Movement of Subcellular Calcium in Bile Pool of Hepatocyte in Rats: Effect of Thyroparathyroidectomy
- Calcitonin Increases Pyruvate Carboxylase Activity in Hepatic Mitochondria of Rats
- Regulatory Effect of Endogenous Calcitonin on Calcium Metabolism in Hepatic Bile System of Rats
- Comparison of Calcitonin, Epinephrine and Glucagon Effects on Plasma Membrane Ca-ATPase Activity and Calcium Content in Liver of Rats
- Calcitonin Stimulates Gluconeogenesis in Fasted Rats
- Effect of Parathyroid Hormone on the Increase in Serum Glucose and Insulin Levels After a Glucose Load to Thyroparathyroidectomized Rats
- Calcitonin Stimulates Glycogenolysis in the Liver of Fasted Rats
- Effect of Calcitonin on Calcium Concentration in Serum and Liver of Rats Ligated Bile Duct
- Preparation of CuGaS_2/ZnS Structures on GaAs(100) Substrate by Pulsed Excimer-Laser Deposition
- Calcitonin Increases Calcium Content and Phosphorylase a Activity in the Hepatic Particulate Glycogen of Rats