INTERACTION OF CALCITONIN AND HISTAMINE ON BILE CALCIUM EXCRETION IN THYROPARATHYROIDECTOMIZED RATS
スポンサーリンク
概要
- 論文の詳細を見る
The effects of calcitonin (CT) and histamine on calcium metabolism in the hepatic bile system of rats were investigated. The subcutaneous administration of CT (20 and 80 MRC mU/100g) to rats caused a significant fall in serum calcium and a marked increase in liver calcium. The subcutaneous administration of histamine (0.1 mg/100 g) to rats produced a significant decrease in serum calcium, while it did not significantly alter liver calcium. However, the effects of CT (20 or 80 MRC mU/100 g) on the serum and liver calcium was markedly prevented by the simultaneous administration of histamine (0.1 mg/100 g). On the other hand, the excretion of calcium into the bile of thyroparathyroidectomized rats intraperitoneally injected with the calcium chloride (4.0 mg Ca/100 g) was markedly increased by the administration of CT (20 or 80 MRC mU/100 g) or histamine (0.1 mg/100 g). Reversely, a remarkable elevation of bile calcium by CT was clearly prevented by the simultaneous administration of histamine (0.1 mg/100 g). The present results further support the point of view that the hypocalcemic effect of CT is based on the stimulation of calcium excretion into the bile by the hormone.
- 公益社団法人日本薬学会の論文
著者
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Okada Shoji
Department of Radiobiochemistry, School of Pharmaceutical Sciences, University of Shizuoka
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YAMAGUCHI Masayoshi
Department of Legal Medicine, Kinki University School of Medicine
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Okada Shoji
Department Of Environmental Biochemistry Shizuoka College Of Pharmacy
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Yamaguchi Masayoshi
Department Of Environmental Biochemistry Shizuoka College Of Pharmacy
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AKIYAMA YOSHIZO
Department of Environmental Biochemistry, Shizuoka College of Pharmacy
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Akiyama Yoshizo
Department Of Environmental Biochemistry Shizuoka College Of Pharmacy
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Okada Shoji
Department Of Environmental Biochemistry Shizoka College Of Pharmacy
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Yamaguchi Masayoshi
Department Of Electrical Engineering Nagaoka University Of Technology
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YAMAGUCHI Masayoshi
Department of Environmental Biochemistry, Shizuoka College of Pharmacy
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