Calcitonin Stimulates Gluconeogenesis in Fasted Rats
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The effect of calcitonin (CT) on gluconeogenesis was studied in fasted rats. The subcutaneous administration of CT (80MRCmU/100g BW) produced a significaut increase in serum glucose concentration and a corresponding decrease in serum lactic acid, free fatty acid and alanine concentrations. These alterations were dose-dependent (20 and 40MRC mU/100g BW). On the other hand, the serum glucose concentration was significantly elevated by a single intraperitoneal injection of alamine (100mg/100g BW). This increase was markedly enchanced by CT administration, and the appreciable effect was observed at a dose of 20MRCmU/100g BW. Also, the significant increase in serum glucose concentration caused by the injections of lactate, pyruvate, and α-ketoglutarate (100mg/100g BW, respectively) was further enhanced by CT administration. The present results indicate that CT stimulates gluconeogenesis in fasted rats.
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