Movement of Subcellular Calcium in Bile Pool of Hepatocyte in Rats: Effect of Thyroparathyroidectomy

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The movement of subcellular calcium in the bile pool of hepatocyte was investigated after a single intraperitoneal administration of calcium chloride in rats. The administration of calcium (4.0 mg/100 g BW) produced a remarkable elevation of serum calcium and a corresponding increase in liver calcium. The calcium taken by the liver cells at 10 min after calcium administration was markedly located into the nuclei, mitochondria and microsomes, and this distribution was not accompanied by a significant elevation in the cytosol level. At 20 min after calcium administration, the calcium increase above the subcellular structure was clearly reduced. On the other hand, serum calcium was markedly increased by calcium administration in both intact and thyroparathyroidectomized rats. However, the liver calcium increase induced in intact rats by calcium administration was much more than that in thyroparathyroidectomized rats. Also, the bile calcium level was markedly elevated by calcium administration in intact rats, but no elevation was observed in thyroparathyroidectomized rats. The present results suggest that the calcium taken by the liver cells is bound to the nuclei, mitochondria and microsomes, and then transported into the biliary duct.
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