STIMULATION OF BONE RESORPTION BY COMPARATIVELY HIGH DOSE OF ZINC IN RATS
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概要
- 論文の詳細を見る
The changes of femoral calcium and acid phosphatase activity were examined in rats orally administered zinc sulfate (10 mg Zn/100 g body weight) for 3 d. Zinc administration to intact rats produced significant decreases of calcium levels in the serum, and femoral diaphysis and epiphysis, while it caused remarkable elevation of acid phosphatase activity in the femoral diaphysis and epiphysis. Thyroparathyroidectomy significantly prevented the alterations of the calcium content and the enzyme activity in the femoral diaphysis and epiphysis caused by zinc administration to intact rats. The present results suggest that comparatively high dose of zinc may stimulate bone resorption mainly mediated through the actions of parathyroid hormone, due to maintain calcium homeostasis.
- 公益社団法人日本薬学会の論文
著者
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Okada Shoji
Department of Radiobiochemistry, School of Pharmaceutical Sciences, University of Shizuoka
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YAMAGUCHI Masayoshi
Department of Legal Medicine, Kinki University School of Medicine
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Okada Shoji
Department Of Environmental Biochemistry Shizuoka College Of Pharmacy
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Yamaguchi Masayoshi
Department Of Environmental Biochemistry Shizuoka College Of Pharmacy
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MOCHIZUKI ATSUYO
Department of Environmental Biochemistry, Shizuoka College of Pharmacy
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Okada Shoji
Department Of Environmental Biochemistry Shizoka College Of Pharmacy
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Mochizuki Atsuyo
Department Of Environmental Biochemistry Shizuoka College Of Pharmacy
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Yamaguchi Masayoshi
Department Of Electrical Engineering Nagaoka University Of Technology
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Okada Shoji
Department of Chemistry, Faculty of Science and Technology, Kinki University
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