Pro-Oxidant Action of Pyrroloquinoline Quinone: Characterization of Protein Oxidative Modifications
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概要
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Pyrroloquinoline quinone (PQQ), a putative essential nutrient, is a redox modulator in cell and animal models. Here we characterized PQQ-induced protein oxidative modifications in a model peptide and protein, and we propose that the mechanism of protein modification by PQQ is redox cycling-mediated oxidation. PQQ may contribute to the regulation of intracellular protein functions through its prooxidant action.
著者
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Ishii Takeshi
Department of Food and Nutritional Sciences, and Global COE Program, University of Shizuoka
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Akagawa Mitsugu
Department of Biological Chemistry, Division of Applied Life Science, Graduate School of Life and En
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Naito Yuji
Department of Molecular Gastroenterology and Hepatology, Graduate School of Medical Science, Kyoto P
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HANDA Osamu
Department of Molecular Gastroenterology and Hepatology, Graduate School of Medical Science, Kyoto P
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TAKAGI Tomohisa
Department of Molecular Gastroenterology and Hepatology, Graduate School of Medical Science, Kyoto P
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MORI Taiki
Department of Food and Nutritional Sciences, and Global COE Program, University of Shizuoka
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KUMAZAWA Shigenori
Department of Food and Nutritional Sciences, and Global COE Program, University of Shizuoka
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YOSHIKAWA Toshikazu
Department of Molecular Gastroenterology and Hepatology, Graduate School of Medical Science, Kyoto P
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NAKAYAMA Tsutomu
Department of Food and Nutritional Sciences, and Global COE Program, University of Shizuoka
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Ishikawa Takeshi
Department Of Molecular Gastroenterology And Hepatology Kyoto Prefectural University Of Medicine
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Naito Yuji
市立奈良病院 消化器肝臓病センター
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