Relation between Polymorphisms G1704T and G82S of RAGE Gene and Diabetic Retinopathy in Japanese Type 2 Diabetic Patients
スポンサーリンク
概要
- 論文の詳細を見る
Objective To clarify whether polymorphisms G1704T and G82S of the RAGE gene were related to diabetic retinopathy, we performed a case-control study in Japanese type 2 diabetic patients.Patients and Methods Two hundred and sixty-eight patients with type 2 diabetes were examined for polymorphisms G1704T and G82S of the RAGE gene. The genotypes of G1704T and G82S of the RAGE gene were determined with a fluorescent allele-specific DNA primer assay system. Diabetic retinopathy (DR) was diagnosed in a masked manner by independent ophthalmologists using fundus photographs and was classified as non-diabetic retinopathy (NDR), non-proliferative retinopathy (NPDR), and proliferative retinopathy (PDR).Results The T allele frequency of G1704T and S allele frequency of G82S in patients with DR did not significantly differ from those without retinopathy. There were no differences among the genotypes of G1704T and G82S of the RAGE gene regarding age, duration of diabetes, BMI, HbA1c, blood pressure, and lipids levels.Conclusion These data suggest that polymorphisms G1704T and G82S of the RAGE gene are not related to DR in Japanese type 2 diabetic patients.
- 社団法人 日本内科学会の論文
- 2005-05-01
著者
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YOSHIKAWA Toshikazu
Department of Molecular Gastroenterology and Hepatology, Graduate School of Medical Science, Kyoto P
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Yoshikawa Toshikazu
Department Of Endocrinology And Metabolism Graduate School Of Medical Science Kyoto Prefectural Univ
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Kogure Akinori
First Department Of Internal Medicine Kyoto Prefectural University Of Medicine
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Kogure Akinori
Department Of Endocrinology Diabetes And Metabolism Kyoto Prefectural University Of Medicine
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Toda Hitoshi
Sakazaki Clinic
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YOSHIDA TOSHIHIDE
Department of Endocrinology, Diabetes and Metabolism, Graduate School of Medical Science, Kyoto Pref
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Umekawa Tsunekazu
First Department Of Internal Medicine Kyoto Prefectural University Of Medicine
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Yoshioka Keiji
Department Of Diabetes And Endocrinology Matsushita Memorial Hospital
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TAKAKURA Yasuto
Department of Endocrinology and Metabolism, Graduate School of Medical Science, Kyoto Prefectural Un
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UMEKAWA Tsunekazu
Department of Endocrinology and Metabolism, Graduate School of Medical Science, Kyoto Prefectural Un
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Yoshida Tsuyoshi
Department Of Nutrition Tokyo Metropolitan Institute Of Gerontology
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Yoshida Toshihide
Department Of Endocrinology And Metabolism Graduate School Of Medical Science Kyoto Prefectural Univ
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Takakura Yasuto
Department Of Endocrinology And Metabolism Graduate School Of Medical Science Kyoto Prefectural Univ
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Yoshioka Keiji
First Department Of Internal Medicine Kyoto Prefectural University Of Medicine
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KOGURE Akinori
Department of Endocrinology and Metabolism, Graduate School of Medical Science, Kyoto Prefectural University of Medicine
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