Effect of Levamisole on the Complement System
スポンサーリンク
概要
- 論文の詳細を見る
Anthelmintic drug levamisole, clinically used as an immunopotentiator, has been shown to restore the decreased cellular immune response. In this experiment, levamisole was found to increase serum complement level either in guinea pig or in human without malignancy, investigated by hemolytic assay using sensitized sheep erythrocytes (EA) for the classical pathway activity and unsensitized rabbit erythrocytes (RaE) for the alternative pathway activity. Assay of complement components revealed a mild increase in Clq, C4, C3, C9, and C1-inhibitor, while no specific tendency was observed in C5, properdin and C3 activator. Although leva misole provided no effect upon serum complement activation in vitro, these evi dences suggested that levamisole might potentiate immune response of the host by elevating serum complement level.
- 一般社団法人 日本臨床薬理学会の論文
著者
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Yoshikawa Toshikazu
Department Of Endocrinology And Metabolism Graduate School Of Medical Science Kyoto Prefectural Univ
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Nishida Koichi
Department Of Hematology Aiseikai-yamashina Hospital
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Kato Haruki
Department of Information and Electronics, Tottori University, Tottori 680-8552, Japan
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WATANABE Koichi
Department of Integrated Biosciences, Graduate School of Frontier Sciences, The University of Tokyo:CREST, Japan Science and Technology Agency(JST)
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NISHIDA Koichi
Department of Medicine, Kyoto Prefectural University of Medicine
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KATO Haruki
Department of Medicine, Kyoto Prefectural University of Medicine
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YOKOE Nobuyoshi
Department of Medicine, Kyoto Prefectural University of Medicine
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TAKEMURA Shuhei
Department of Medicine, Kyoto Prefectural University of Medicine
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MATSUMURA Naoyuki
Department of Medicine, Kyoto Prefectural University of Medicine
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HOTTA Tadahiro
Department of Medicine, Kyoto Prefectural University of Medicine
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FURUKAWA Yasumasa
Department of Medicine, Kyoto Prefectural University of Medicine
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WAKAMATSU Yoshikazu
Department of Medicine, Kyoto Prefectural University of Medicine
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TAGAMI Hiroki
Department of Medicine, Kyoto Prefectural University of Medicine
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KONDO Motoharu
Department of Medicine, Kyoto Prefectural University of Medicine
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