Angelica keiskei Extract Improves Insulin Resistance and Hypertriglyceridemia in Rats Fed a High-Fructose Drink

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概要

• 論文の詳細を見る

• Angelica keiskei is a traditional herb peculiar to Japan and abundantly contains vitamins, dietary fiber and such polyphenols as chalcone. We investigated in the present study the effect of A. keiskei on insulin resistance and hypertriglyceridemia in fructose-drinking rats as a model for the metabolic syndrome. Male Wistar rats were given a 15% fructose solution as drinking water for 11 weeks. Fructose significantly increased the levels of serum insulin and triglyceride (TG) compared with the control level. Treatment with an ethanol extract of A. keiskei (AE) significantly reduced the levels of blood glucose (−16.5%), serum insulin (−47.3%), HOMA-R (−56.4%) and TG (−24.2%). A hepatic gene analysis showed that fructose reduced the expression of the genes related to fatty acid β-oxidation and high-density lipoprotein (HDL) production. Treatment with AE enhanced the expression of the acyl-CoA oxidase 1 (ACO1), medium-chain acyl-CoA dehydrogenase (MCAD), ATP-binding membrane cassette transporter A1 (ABCA1) and apolipoprotein A1 (Apo-A1) genes. These results suggest that AE improved the insulin resistance and hypertriglyceridemia of the fructose-drinking rats.

• Japan Society for Bioscience, Biotechnology, and Agrochemistryの論文
• 2012-05-23

著者

• Yoshikawa Toshikazu

  Department Of Molecular Gastroenterology And Hepatology Kyoto Prefectural University Of Medicine

• Yoshikawa Toshikazu

  Department Of Endocrinology And Metabolism Graduate School Of Medical Science Kyoto Prefectural Univ

• Aoi Wataru

  Department Of Biochemistry Kyoto Prefecture! University

• Kato Ikunoshin

  Takara Bio Inc. Biotechnology Research Laboratories

• Naito Yuji

  市立奈良病院 消化器肝臓病センター

• Enoki Tatsuji

  Biotechnology Research Laboratories Takara Bio Inc.

• Kudo Yoko

  Biotechnology Research Laboratories Takara Bio Inc.

• Naito Yuji

  Department Of Cardiovascular Center Hokkaido Social Insurance Hospital

• Enoki Tatsuji

  Takara Bio Inc.

• Kudo Yoko

  Takara Bio Inc.

• Hayami Shoko

  Takara Bio Inc.

• Aoi Wataru

  Department Of Molecular Gastroenterology And Hepatology Kyoto Prefectural University Of Medicine

• Tanimura Yuko

  Department Of Molecular Gastroenterology And Hepatology Kyoto Prefectural University Of Medicine

• OHNOGI Hiromu

  Department of Molecular Gastroenterology and Hepatology, Kyoto Prefectural University of Medicine

• DEGUCHI Suzu

  Takara Bio Inc.

• MIZUTANI Shigetoshi

  Takara Bio Inc.

• Ohnogi Hiromu

  Department Of Molecular Gastroenterology And Hepatology Kyoto Prefectural University Of Medicine

• Kato Ikunoshin

  Takara Bio Inc.

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