Prophylactic Effect of Rebamipide on Aspirin-Induced Gastric Lesions and Disruption of Tight Junctional Protein Zonula Occludens-1 Distribution
スポンサーリンク
概要
- 論文の詳細を見る
Aspirin and nonsteroidal anti-inflammatory agents are known to induce gastroduodenal complications such as ulcer, bleeding, and dyspepsia. In this study, we examined the prophylactic effect of rebamipide, an anti-ulcer agent with free-radical scavenging and anti-inflammatory effect, on acidified aspirin-induced gastric mucosal injury in rats. In addition, we investigated the mucosal barrier functions disrupted by aspirin. Oral administration of acidified aspirin resulted in linear hemorrhagic erosions with increasing myeloperoxidase activity and thiobarbituric acid-reactive substance concentrations in the gastric mucosa. Rebamipide suppressed these acidified aspirin-induced gastric lesions and inflammatory changes significantly, and its protective effect was more potent in the case of repeated (twice daily for 3 days) treatment than single treatment before aspirin administration. Immunostaining of zonula occludens (ZO)-1, one of the tight junctional proteins, was strengthened in rat gastric mucosa after repeated administration of rebamipide. In addition, aspirin induced the increasing transport of fluorescine isothiocyanate-labeled dextrans with localized disruption and decreased expression of ZO-1 protein on rat gastric mucosal cell line RGM-1. Rebamipide effectively prevented aspirin-induced permeability changes and disruption of ZO-1 distribution. These results suggest that rebamipide protects against aspirin-induced gastric mucosal lesions by preserving gastric epithelial cell-to cell integrity in addition to the anti-inflammatory effects.
- 社団法人 日本薬理学会の論文
- 2008-03-20
著者
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Yoshikawa Toshikazu
Department Of Molecular Gastroenterology And Hepatology Kyoto Prefectural University Of Medicine
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Yoshikawa Toshikazu
Inflammation And Immunology Graduate School Of Medical Science Kyoto Prefectural University Of Medic
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MATSUI HIROFUMI
Department of Gastroenterology, Graduate School of Comprehensive Human Science, University of Tsukub
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YOSHIDA NORIMASA
Molecular Gastroenterology and Hepatology, Kyoto Prefectural University of Medicine, Graduate School
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SUZUKI Takahiro
Inflammation and Immunology, Kyoto Prefectural University of Medicine
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TAKAGI Tomohisa
Inflammation and Immunology, Kyoto Prefectural University of Medicine
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ICHIKAWA Hiroshi
Inflammation and Immunology, Kyoto Prefectural University of Medicine
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NAKABE Nami
Inflammation and Immunology, Graduate School of Medical Science, Kyoto Prefectural University of Med
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ISOZAKI Yutaka
Inflammation and Immunology, Graduate School of Medical Science, Kyoto Prefectural University of Med
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KAJIKAWA Hirokazu
Inflammation and Immunology, Graduate School of Medical Science, Kyoto Prefectural University of Med
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HANDA Osamu
Inflammation and Immunology, Graduate School of Medical Science, Kyoto Prefectural University of Med
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KOKURA Satoshi
Inflammation and Immunology, Graduate School of Medical Science, Kyoto Prefectural University of Med
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NAITO Yuji
Inflammation and Immunology, Graduate School of Medical Science, Kyoto Prefectural University of Med
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Ichikawa Hiroshi
Department Of Molecular Gastroenterology And Hepatology Kyoto Prefectural University Of Medicine
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Matsui Hirofumi
Department Of Gastroenterology Institute Of Clinical Medicine University Of Tsukuba
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Matsui Hirofumi
Department Of Chemistry And Materials Technology Kyoto Institute Of Technology
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Naito Yuji
市立奈良病院 消化器肝臓病センター
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Nakabe Nami
Inflammation And Immunology Graduate School Of Medical Science Kyoto Prefectural University Of Medic
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Handa Osamu
Department Of Molecular Gastroenterology And Hepatology Kyoto Prefectural University Of Medicine
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Kokura Satoshi
Department Of Molecular Gastroenterology And Hepatology Kyoto Prefectural University Of Medicine
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Isozaki Yutaka
Inflammation And Immunology Graduate School Of Medical Science Kyoto Prefectural University Of Medic
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Takagi Tomohisa
Department Of Molecular Gastroenterology And Hepatology Kyoto Prefectural University Of Medicine
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Yoshida Norimasa
Department Of Molecular Gastroenterology And Hepatology Kyoto Prefectural University Of Medicine
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Kajikawa Hirokazu
Inflammation And Immunology Graduate School Of Medical Science Kyoto Prefectural University Of Medic
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Yoshikawa Toshikazu
Department Of Molecular Gastroenterology And Hepatology Graduate School Of Medical Science Kyoto Pre
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Kokura Satoshi
Department Of Molecular Gastroenterology And Hepatology Graduate School Of Medical Science Kyoto Pre
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Suzuki Takahiro
Inflammation And Immunology Graduate School Of Medical Science Kyoto Prefectural University Of Medic
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Kokura Satoshi
Inflammation And Immunology Graduate School Of Medical Science Kyoto Prefectural University Of Medic
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Yoshida Norimasa
Molecular Gastroenterology And Hepatology Graduate School Of Medical Science Kyoto Prefectural Unive
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Yoshikawa Toshikazu
Department Of Molecular Gastroenterology And Hepatology Graduate School Of Medical Science Kyoto Pre
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